CENTER OF EXCELLENCE FOR PROSTATE CANCER RESEARCH, EDUCATION AND COMMUNITY SERVIC

简介（由申请人提供）：癌症研究与治疗发展中心（CCRTD）于1999年在克拉克亚特兰大大学成立，开展癌症生物学和药物发现的基础研究。2004年，由于非裔美国男性前列腺癌的发病率和死亡率高得不成比例，CCRTD决定将重点放在前列腺癌领域。目前的提案要求支持建立一个卓越的前列腺癌研究、教育和社区教育中心。该中心的主要目标是：1)开展前列腺癌细胞和分子生物学的高质量基础研究，并找出种族差异的潜在生物学原因；2)为本科生和研究生建立研究培训计划，提供前列腺癌领域的研究培训，从而增加该领域少数民族（主要是非裔美国人）科学家的数量。3)建立以社区为基础的教育项目，提高人们对前列腺癌的预防、筛查、早期发现和治疗的认识。这一目标将与克拉克亚特兰大大学Whitney M. Young, Jr.社会工作学院，传播艺术系和中城泌尿学教育基金会合作实现。在研究核心中，我们提出了3个研究项目和6个试点项目，重点研究前列腺癌细胞和分子生物学以及种族差异。在培训核心中，我们要求支持癌症生物学和社区服务领域的三名研究生和五名本科生的培训。在社区外联/教育核心方面，我们请求支持开展社区活动，为非裔美国人男子进行免费健康检查，举办由中央大学电视台和广播电台播放的“市政厅”教育会议，制作公益广告，并在我们每年一次的全国前列腺癌专题讨论会的同时举办社区活动。该中心的全面活动将由行政核心监督。行政核心的活动将由机构咨询委员会、外部咨询委员会和地方外部咨询委员会监督。该中心的长期目标将是了解前列腺癌的生物学，增加从事癌症研究的非裔美国科学家的数量，并在前列腺癌预防、早期发现和治疗方面教育非裔美国人社区。

DESCRIPTION (provided by applicant): The Center for Cancer Research and Therapeutic Development (CCRTD) was established in 1999 at Clark Atlanta University to carry-out basic research in cancer biology and drug discovery. In 2004, the CCRTD decided to concentrate in the area of prostate cancer due to disproportionately higher incidence and mortality rate of this disease in African-American men. The current proposal requests support to establish a Center of Excellence in prostate cancer research, education and community education. The main objectives of this center will be 1) To carry out high quality basic research in cell and molecular biology of prostate cancer and to identify underlying biological reasons for racial disparities, 2) To establish a research training program for undergraduate and graduate students to provide research training in the area of prostate cancer and hence increase the number of minority (primarily African-American) scientists in this area of research, 3) To establish a community-based educational program for raising awareness on prevention, screening, early detection and treatment of prostate cancer. This goal will be achieved in collaboration with Clark Atlanta University Whitney M. Young, Jr. School of Social Work, Division of Communication Arts and Midtown Urology Educational Foundation. In the Research Core, we propose three research projects and 6 pilot projects focusing on prostate cancer cell and molecular biology and racial disparities. In the Training Core, we are requesting support for training of three graduate and 5 undergraduate students in the area of cancer biology and community service. In the Community Outreach/Education Core, we are requesting support to establish community events for free health screening for African-American men, for holding "Town Hall" educational meetings to be broadcast by the CAU-TV and radio stations, to develop public service announcements, and for hosting community events in conjunction with our annual national symposium on prostate cancer. The overall activities of the center will be monitored by the Administrative Core. The activities of the Administrative Core will be overseen by the Institutional (IAC), External (EAC) and Local External (LEAC) Advisory Committees. The long term goals of the center will be to understand the biology of prostate cancer, to increase the number of African-American scientists in cancer research, and to educate the African-American community in the areas of prostate cancer prevention, early detection and treatment.