Institutional Research Cancer Epidemiology Fellowship

本提案是重新提交的申请，要求对（NRSA机构研究）进行5年续期（24-28年） 资助约翰霍普金斯彭博癌症流行病学、预防和控制培训项目 公共卫生学院。该计划的使命是培养博士前的学生和博士后研究员成为 领导人在推进癌症的原因，包括遗传和可变因素的知识的前沿， 以及如何通过更好地了解癌症相关行为和识别新的标志物来预防癌症 在人群研究中早期发现癌症。该计划的目标是创造一个丰富的和互动的 通过高度创新，富有成效和协作的癌症研究为学员提供环境 由公共卫生学院，Kimmel癌症中心和Johns的观察，基础和临床科学家 霍普金斯医疗机构。该计划的主题体现在3个互补的培训轨道：1）癌症 病因学和预防; 2）癌症遗传流行病学; 3）癌症控制。7名博士生和4名博士后 受训人员参加一个有重点的方案，其中包括跨轨道的共同要素： 学科内和跨学科的方法论问题和研究伦理;互动信息交流，包括 正在进行的研究，研讨会和专题讨论会;教学，交流，授予写作经验;实践 通过流行病学和实验室对现有数据集进行统计分析和短期轮换的经验 癌症研究计划（pre-doc）;在从事导师的指导下进行博士前或博士后研究;以及特定计划 教育、研究和职业指导。我们强调开发和测试新的生物学- 基于假设和跨学科合作。通过共享的元素，我们的学员接触到电流 问题，如转化研究，分子流行病学，新出现的癌症风险因素，方法学问题 在癌症研究和筛查、癌症差异、烟草控制、肥胖/能量平衡、炎症和使用 风险评估和公共政策中的流行病学。修订后的计划建立在一个有着长期记录的计划的基础上， 根据现任和前任学员、外部顾问和同行的评价， 审稿人。该方案有19名负责初级指导的导师。额外39 附属教师已书面承诺提供特定癌症部位，生物统计学和实验室的专业知识， 基于接触评估;他们聚集在一起，使广度和深度，以学员的经验，并满足 随着科学的进步，他们不断变化的需求。指导委员会负责受训人员的挑选和监测， 并随着这些领域的发展而完善培训计划。该提案记录了明确的培训记录， 导师制;过去10年获委任的23名博士前及10名博士后研究生均从事癌症研究工作。 成功从大量的申请者中，我们招募了代表不同背景的最佳候选人。 总之，该计划的目的是为学员提供必要的多学科背景进行 最高水平的最先进的合作癌症研究，培养创新思维和教学能力， 沟通，并准备他们在国家的人口为基础的癌症研究议程的领导者。

This proposal is a resubmission of an application for a 5-year renewal (Years 24-28) of(an NRSA Institutional Research Grant for the training program in Cancer Epidemiology, Prevention, and Control at the Johns Hopkins Bloomberg School of Public Health. The program mission is to train pre-doctoral students and post-doctoral fellows to become leaders at the forefront of advancing the knowledge of the causes of cancer, including genetic and modifiable factors, and how to prevent cancer by providing a better understanding of cancer-related behaviors and identifying new markers for the early detection of cancer in population-based studies. The program goal is to create a rich and interactive environment for trainees augmented by the highly innovative, productive, and collaborative cancer research conducted by observational, basic, and clinical scientists at the School of Public Health, Kimmel Cancer Center, and Johns Hopkins Medical Institutions. The program themes are embodied in the 3 complementary training tracks: 1)Cancer Etiology and Prevention; 2) Genetic Epidemiology of Cancer; and 3) Cancer Control. The 7 pre-and 4 post-doctoral trainees pursue a focused program consisting of shared elements across the tracks: didactic courses in substantive and methodologic issues within and across disciplines and research ethics; interactive information exchange including research in progress, seminars, and symposium; teaching, communication, grant writing experiences; practical experiences of a statistical analysis of an existing dataset and short rotations through epidemiology and laboratory cancer research programs (pre-doc); pre- or post-doctoral research under an engaged preceptor; and program-specific education, research, and career mentoring. We stress the importance of developing and testing novel biologically- based hypotheses and collaborating across disciplines. Via the shared elements, our trainees are exposed to current issues, such as translational research, molecular epidemiology, emerging risk factors for cancers, methodologic issues in cancer research and screening, cancer disparities, tobacco control, obesity/energy balance, inflammation, and use of epidemiology in risk assessment and public policy. The revised program builds on a program with a long track record, with major changes made in response to evaluations from current and former trainees, an external advisor, and peer reviewers. The program has a core of 19 preceptors who are responsible for primary mentoring. An additional 39 affiliated faculty have committed in writing to providing expertise in specific cancer sites, biostatistics, and laboratory- based exposure assessment; they were assembled to bring breadth and depth to the trainees' experiences and to meet their changing needs as science advances. A Steering Committee is responsible for trainee selection and monitoring, and refinement of the training program as these fields progress. The proposal documents a clear record of training and mentorship; the 23 pre- and 10 post-doctoral trainees appointed in the past 10 years have cancer research career success. From a large pool of applicants, we recruit the best possible candidates who represent diverse backgrounds. In summary, the program is designed to provide trainees with the multidisciplinary background essential to conduct the highest caliber state-of-the-art collaborative cancer research, to nurture innovative thinking and the ability to teach and communicate, and to prepare them to be leaders in the Nation's population-based cancer research agenda.