Developmental Activities

附属活动的总体愿景 在我们的CCNE的过去5年中，研究人员对通过试点项目和/或合作研究加入该联盟表现出极大的兴趣。我们认为这些项目是CCNE使命的重要辅助，从中可以产生完整的项目和重要的科学。例如，在过去，我们的财团资助了选定的以下项目： 哈蒙德和戴恩·维特鲁普（试点项目），用于肿瘤选择性核酸递送的官能化线性-树枝状二嵌段共聚物。其中一位博士后（Greg Thurber）现在在Weissleder实验室工作，并限制相互作用（85，86） <$Stephen Lippard（试点项目）用含有DNA双链体的金纳米粒子进行功能化 与Chad Mirkin合作， 西北CCNE（87） <$Robert Westen/elt（试点项目）关于混合集成电路/微流控芯片用于操纵 细胞（88，89） <$Sridhar Ramaswamy（试点项目）转移性癌症的纳米模型（90） Mehmet Toner和丹尼尔哈伯（试点项目）对循环肿瘤细胞的微流体分选。这 最初的试点项目产生了几个高影响力的出版物（91-93）和资金以外的 包括最近的SU 2C赠款，涉及几个CCNE成员（Bhatia，Weissleder）。 试点、联盟挑战和其他探索性项目提供了一种机制， 研究人员，并迅速资助最有前途的想法。以下部分列出了我们持续发展活动的一些总体计划。

OVERALL VISION FOR DEVELOPMENTAL ACTIVITIES Over the last 5 years of our CCNE, there has been a tremendous interest by researchers to join the consortium through pilot projects and/or collaborative research. We view such projects as an important adjunct of the CCNE's mission and from which full projects and important science can emerge. For example, in the past our consortium has funded the selected following projects: ¿ Paula Hammond and Dane Wittrup (pilot project) on functionalized linear-dendritic diblock copolymers for tumor-selective nucleic acid delivery. One ofthe postdocs (Greg Thurber) now works in the Weissleder lab and confinues interactions (85, 86) ¿ Stephen Lippard (pilot project) on functionalizing gold nanoparticles with DNA duplexes containing tethered, releasable plafinum conjugates at their termini in collaboration with Chad Mirkin at Northwestern CCNE (87) ¿ Robert Westen/elt (pilot project) on hybrid integrated circuit/microfluidic chips forthe manipulation of cells (88, 89) ¿ Sridhar Ramaswamy (pilot project) on nanomodels of metastatic cancer (90) ¿ Mehmet Toner and Daniel Haber (pilot project) on microfluidic sorting of circulating tumor cells. This original pilot project has resulted in several high impact publications (91-93) and funding outside the consortium, including a recent SU2C grant involving several CCNE members (Bhatia, Weissleder). Pilot, Alliance Challenge and other exploratory projects provide a mechanism by which to attract new researchers and to rapidly fund the most promising ideas. The following section lists some of our general plans on continuing developmental activities.