REGIONAL VARIATION IN D1 SIGNALING PROTEIN LOCALIZATION

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 我们已确定D1族多巴胺受体亚型D1D5分别定位于前额叶皮质(PFC)、杏仁核和伏核(NAC)的环路中。 这些研究的结果被用来提出一种新的机制来解释多巴胺刺激D1家族受体与工作记忆功能的关系。我们对信号转导蛋白的研究已经完成，手稿正在准备或审查中。 这项优秀奖已经更新，现在将扩大我们对杏仁核的研究，以努力了解压力如何改变这一关键大脑区域的连接。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We have determined that the D1 family dopamine receptor subtypes, D1 and D5 are differentially localized within the circuitry of prefrontal cortex (PFC), amygdala and nucleus accumbens (NAc). The results of these studies have been used to propose a novel mechanism to explain the relationship between dopamine stimulation of D1 family receptors and working memory function. Our studies of signal transduction proteins are completed and manuscripts are in preparation or in review. This merit award has been renewed and will now expand on our studies of the amygdala in an effort to understand how stress alters the wiring of this critical brain region.