Sensory processing deficits in the schizophrenia prodrome

该项目代表了两种理论方法的创新整合，具有巨大的潜力， 改善对精神分裂症的预测，并有助于阐明发病的神经机制 精神病虽然青春期后期/成年早期是发病的典型时期，但很少有 前瞻性前驱期研究集中在这一时期发生的脑功能变化上。 在发育的早期阶段，有关导致疾病的神经过程的信息， 提高准确的预测，并可能导致针对特定异常的新干预措施 鉴定拟议的项目结合了两个既定的调查人员（Cornblatt和 Javitt），他们目前正在合作研究D-丝氨酸对SZ前驱症状的影响， 提供资金和资源，将Javitt博士的生物学方法引入Cornblatt博士的 前瞻性纵向前驱期研究。康布拉特博士进行了一项研究 神经认知、行为和临床危险因素的研究。自1998年以来，她 我是识别和预防（RAP）项目的负责人，这是一项针对青少年的前瞻性研究 处于临床风险的12-22岁之间的人（即，在Zucker希尔赛德治疗精神分裂症 医院（ZHH）。她将担任该项目的PI。该项目将纳入与事件相关的潜力 (ERP)和感觉处理功能障碍的行为措施，以提高现有的神经认知 电池.该项目的具体目标是1。引入感觉处理电池（行为 评估在何种程度上， 缺陷存在于疾病的前驱期; 2.评估短期的感觉变化， 无药物治疗受试者与稳定药物治疗受试者相比， 药物，3。以评估与两年复检相关的长期处理变化。我们有 选择跟踪所有参与者两年，因为以前的调查结果表明， 这段时间，可以预计约为35%。本项目的主要ERP支持将是 由核心B提供。将对项目1、5和6的ERP措施进行比较，以评估 慢性、前驱和首次发作队列。该项目也与数据库集成 项目6的组成部分，并将获得核心C的数据库和统计支持。 相关性（参见说明）： 精神分裂症是一种严重的精神障碍。神经认知功能障碍是 精神分裂症和长期预后不良的主要决定因素。该项目是一个中心的一部分 应用于确定精神分裂症神经认知功能障碍的脑机制 特别强调感觉处理功能障碍。该项目将评估 精神分裂症前驱症状患者的感觉加工 与其他项目和核心计划，作为一种方式，以提高早期检测和干预。

This Project represents an innovative integration of two theoretical approaches that have great potential for improving prediction of schizophrenia and for helping to clarify the neural mechanisms involved in the onset of psychosis. Although late adolescence/eariy adulthood is the period when onset typically occurs, few prospective prodromal studies have focused on the changes in brain function that occur during this period. Information about the neural processes leading to illness during this eariy phase of development could both improve accurate prediction and potentially lead to novel interventions targeting the specific abnormalities identified. The proposed Project combines the expertise of two established investigators (Cornblatt and Javitt) who currently collaborate on studies of D-serine effects on symptoms in the SZ prodrome, and will provide the funding and resources to introduce Dr. Javitt's biological approach into Dr. Cornblatt's prospective, longitudinal prodromal study. Dr. Cornblatt has conducted research concerned with identifying neurocognitive, behavioral and clinical risk factors of schizophrenia for over 20 years. Since 1998, she has been the director of the Recognition and Prevention (RAP) program, a prospective study of adolescents between the ages of 12-22 who are at clinical risk (i.e., prodromal) for schizophrenia at Zucker Hillside Hospital (ZHH). She will serve as PI for this project. The project will incorporate event-related potential (ERP) and behavioral measures of sensory processing dysfunction to enhance existing neurocognitive batteries. Specific aims of the project are 1. to introduce a sensory processing battery (behavioral measures/ERP procedures) to the existing RAP baseline procedures and assess the extent to which sensory deficits are present in the prodromal stage of illness; 2. to evaluate short-term changes in sensory processing and ERPs at six months in subjects who are medication free as compared to those stabilized on medication, and 3. to assess long-term change in processing associated with a two-year retest. We have elected to follow all participants for two years, since previous findings indicate that conversions peak during this time period, and can be expected to be about 35%. Primary ERP support for this Project will be provided by Core B. ERP measures will be compared across Project 1, 5 and 6 to assess deficits in chronic, prodromal and first episode cohorts, respectively. This project integrates as well with database component of Project 6, and will receive database and statistical support from Core C. RELEVANCE (See instructions): Schizophrenia is a major mental disorder. Neurocognitive dysfunction is a core component of schizophrenia and a major determinant of poor long-term outcome. This project is part of a Center application to determine brain mechanisms underiying neurocognitive dysfunction in schizophrenia with particular emphasis on sensory processing dysfunction. This project will evaluate deficits in sensory processing in patients showing prodi^omal symptoms of schizophrenia , in collaboration with other projects and core programs, as a way to improve eariy detection and intervention.