Imaging

成像核心将提供所需的科学和技术专长，以履行所有的CT和 项目的MR成像需求。通过单一核心提供所有成像服务将避免重复 关于人类研究和监管问题的努力，扫描方案的制定，主题 扫描过程中的管理和图像分析技术。图像分析方法将集中在 CT和MR的肺气肿量化，以及CT的气道和气道壁尺寸。 通过单个核心执行所有程序将确保一致的成像和分析方法 在项目之间，促进成像数据的比较和相关性。 成像核心将由多学科团队的成员组成 （包括放射科医生、物理学家、肺病学家、病理学家和外科医生）， 他对COPD的MR评估可以追溯到七年前。我们使用这些成像技术的经验 技术开始于肺减容术中严重COPD患者的特征描述， 我们机构的手术计划（1-7）。它涉及对CT技术因素影响的调查 肺衰减测量（8-10），3 He MR成像中涉及的技术因素（11-13），以及评价 肺组织微结构的~ 3 He MR研究（14）。我们已经进行了肺气肿相关的定量分析， CT扫描200余例，3 He MR成像50余例（其中33例为高级MRI）， COPD），并在正在进行的研究中使用CT和3 He MR对30多个经处理的肺标本进行成像。 该中心提供的服务将包括：协助人类研究和监管问题; 制定和实施扫描和图像重建协议;制作 磁共振成像用超极化3 He气体;磁共振成像线圈的设计和结构; CT和MR性能 扫描; CT扫描的临床解释;图像处理和分析;图像和原始数据的存档; 并根据需要协助图像去识别。项目1将使用CT和MR成像核心 成像、图像分析和相关服务。项目3将使用Core进行CT成像、图像分析， 和相关服务，并用于分析潜在受试者的现有CT扫描，以确定是否存在 肺气肿项目4和项目5将使用成像核心进行CT成像、图像分析和相关 服务

The Imaging Core will provide the scientific and technical expertise needed to fulfill all of the CT and MR imaging needs of the Projects. Providing all imaging services through a single core will avoid duplication of effort regarding Human Studies and regulatory issues, development of scanning protocols, subject management during scanning, and image analysis techniques. Image analysis methods will focus on the quantification of emphysema for both CT and MR, and also airway and airway wall dimensions with CT. Performing all procedures through a single Core will insure consistent imaging and analysis methodology among the Projects, facilitating comparison and correlation of imaging data. The Imaging Core will be comprised of individuals that have been part of a multidisciplinary team (which includes radiologists, physicists, pulmonologists, pathologists, and surgeons) involved in the CT and He MR evaluation of COPD that dates back over seven years. Our experience with the use of these imaging techniques began with the characterization of patients with severe COPD in the Lung Volume Reduction Surgery program at our institution (1-7). It has involved investigations into the impact of technical factors on CT measurements of lung attenuation (8-10), technical factors involved in 3He MR imaging (11-13), and evaluation of the lung microstructure with 3He MR (14). We have performed emphysema-related quantitative analysis of CT scans in over 200 patients, imaged more than 50 subjects with 3He MR (including 33 with advanced COPD), and imaged more than 30 explanted lung specimens with both CT and 3He MR in ongoing studies. Services provided by the Core will include: assistance with Human Studies and regulatory issues; development and implementation of scanning and image reconstruction protocols; production of hyperpolarized 3He gas for MR imaging; MR imaging coil design and construction; performance of CT and MR scans; clinical interpretation of CT scans; image processing and analysis; archiving of images and raw data; and assistance with image deidentification as needed. Project 1 will use the Imaging Core for CT and MR imaging, image analysis, and associated services. Project 3 will use the Core for CT imaging, image analysis, and associated services, and for analysis of existing CT scans of potential subjects for the presence emphysema. Projects 4 and 5 will use the Imaging Core for CT imaging, image analysis, and associated services.