Training Grant in Mechanisms of Vascular Disease

描述（由申请人提供）：血管疾病机制培训计划的竞争性更新申请将范德比尔特大学和Meharry医学院血管生物学多学科研究的优势和多样性整合为新研究科学家专门培训的凝聚力计划。范德比尔特的参与部门包括生物化学，生物医学工程，癌症生物学，细胞与发育生物学，微生物学与免疫学，分子生理学与生物物理学，病理学，药理学，医学和儿科学，在Meharry，微生物发病机制和免疫反应，神经生物学和神经毒理学。培训将在五个不同的研究领域提供，相互关联 他们专注于血管生物学的重要方面。这些领域是：（1）微生物血管疾病;（2）动脉粥样硬化、肥胖和高血压;（3）心血管发育和血管生成;（4）血管生成和组织重塑;（5）血栓形成和止血。这些广泛定义的研究领域侧重于推进对血管疾病的机制的理解，包括：病毒，细菌或寄生虫感染，这些感染会导致心血管系统传播疾病;动脉粥样硬化及其与肥胖和高血压的关系;发育性和先天性心血管疾病及其修复;与肿瘤发生相关的血管生成以及细胞外基质和分子介质的作用;以及中风和心脏病发作中血栓形成的分子和细胞机制。每个重点领域由5-10名调查员组成。该计划将支持5名博士前和3名博士后（M.D.和/或博士学位）实习生博士预科训练将使学生获得一门基础科学的学位。论文 研究将侧重于培训补助金导师专门领域内的一个项目。博士后培训将主要包括实验室研究的指导下，教师导师从培训补助金和共同导师。所有博士前和博士后学员都必须参加这些课程。血管疾病的细胞和分子基础，由参与教师讲授，科学传播基础和生物统计学课程，以及其他课程，取决于学员的背景和专业研究兴趣。学员还必须参加血管生物学和正在进行的研讨会，年度血管生物学务虚会，选定的部门研究研讨会，并在负责任的研究行为的培训。参与教师的实验室有充足的空间和最先进的仪器。

DESCRIPTION (provided by applicant): This application for competing renewal of the Training Program in Mechanisms of Vascular Disease integrates the strength and diversity of multidisciplinary research In vascular biology at Vanderbilt University and Meharry Medical College into a cohesive program for specialized training of new research scientists. Participating departments at Vanderbilt include Biochemistry, Biomedical Engineering, Cancer Biology, Cell & Developmental Biology, Microbiology & Immunology, Molecular Physiology & Biophysics, Pathology, Pharmacology, Medicine, and Pediatrics, and at Meharry, Microbial Pathogenesis and Immune Response and Neurobiology and Neurotoxicology. Training will be offered in five diverse areas of research, interconnected by their focus on significant aspects of vascular biology. The areas are: (1) Microbial Vascular Diseases; (2) Atherosclerosis, Obesity, and Hypertension; (3) Cardiovascular Development and Vasculogenesis; (4) Angiogenesis and Tissue Remodeling; and (5) Thrombosis and Hemostasis. These broadly defined research areas focus on advancing the understanding of the mechanism(s) underlying vascular diseases including; viral, bacterial, or parasitic Infections that commandeer the cardiovascular system to propagate disease; atherosclerosis and its relationship to obesity and hypertension; developmental and congenital cardiovascular diseases and their repair; angiogenesis associated with tumorlgenesis and the role of extracellular matrix and molecular mediators; and molecular and cellular mechanisms of thrombosis in stroke and heart attack. Each focus area consists of 5-10 investigators. The program will support 5 predoctoral and 3 postdoctoral (M.D. and/or Ph.D.) trainees. Predoctoral training will lead to a degree In one of the basic sciences. Dissertation research will focus on a project within the specialized area of a training-grant mentor. Postdoctoral training will consist primarily of laboratory research under the guidance of a faculty mentor from the training grant and a co-mentor. All predoctoral and postdoctoral trainees will be required to participate in the courses. Cellular and Molecular Basis of Vascular Disease, taught by the participating faculty, courses on Fundamentals of Scientific Communication, and Biostatistics, and other courses depending on the background and specialized research interests of the trainee. Trainees are also required to participate in the Vascular Biology and Workin- Progress Seminars, the annual Vascular Biology Retreat, selected departmental research seminars, and training in Responsible Conduct of Research. Ample space and state-of-the-art instrumentation are available in the laboratories of the participating faculty.