Multidisciplinary Psychiatry Genetics Training Program

描述（由申请人提供）：本申请的精神病学、人类遗传学、神经生物学、统计学和心理学部门的中心目标是在行为、神经科学和遗传学方面产生创新的生物医学研究。自2002年成立以来，该培训项目专注于复杂遗传精神疾病遗传学的跨学科方法，包括基础研究和技术开发，每年有两个博士后名额。现有的研究优势包括双相情感障碍和精神分裂症的分子遗传学研究、行为障碍和治疗的转基因小鼠模型的开发、DNA序列和单倍型图谱的生物信息学研究、复杂表型遗传分析方法的开发、遗传变异的进化和流行病学分析以及临床研究中的微阵列方法。培训项目坐落在一个鼓励跨学科研究合作的环境中。已经确定并招募了两种类型的学员：1)行为卫生保健专业人员（医学博士或其他博士学位），具有相关临床或基础研究的职业潜力，如家庭研究、遗传流行病学和临床转化研究；2)具有相应基础和应用科学领域的博士学位，包括群体遗传学、分子和细胞神经生物学、认知和系统神经科学、遗传流行病学和生理心理学。我们很幸运地用优秀的研究员填补了所有的空缺；三名行为卫生保健专业人员和一名基础/转化博士完成了我们的课程。此外，博士和医学博士/博士的学生谁参加了我们的教学调查课程学分提供招聘机会，在未来几年。对于每个受训者，该项目包括正式的课程学习，由项目教师举办的一系列研讨会，在项目开始时在几个实验室轮换（如果合适的话），并在他们选择的实验室进行强化指导培训。在适当的情况下提供双重临床/基础指导。所有研究员都要参加大学临床研究培训计划的入门课程，并参加由神经生物学委员会以及精神病学、统计学、健康研究、心理学和人类遗传学部门提供的适当研究生课程。为了促进研究员和导师之间的互动，受训者每年举办研讨会，并有机会在一年一度的芝加哥大学神经科学日上展示他们的成就。基于这个计划在最初训练期间的成功，我们请求T32奖助金的续期，并将奖学金名额从每年2个增加到3个。

DESCRIPTION (provided by applicant): The central goal of the Departments in this application, Psychiatry, Human Genetics, Neurobiology, Statistics, and Psychology, is generating innovative biomedical research in behavior, the neurosciences, and genetics. This training program has focused on interdisciplinary approaches to genetics of complex inheritance psychiatric disease, including basic research and technology development, since its inception in 2002, with two postdoctoral slots per year. Existing research strengths include molecular genetic research into bipolar illness and schizophrenia, development of transgenic murine models of behavioral disorders and treatment, bioinformatics of DNA sequence and haplotype maps, development of methods for genetic analysis of complex phenotypes, evolutionary and epidemiologic analysis of genetic variation, and microarray methods in clinical investigation. The training program is situated in an environment which encourages interdisciplinary research collaborations. Two types of trainees have been identified and recruited: 1) behavioral health care professionals (MDs or other doctoral degree) with demonstrated potential for a career in pertinent clinical or basic research, such as family studies, genetic epidemiology, and clinical translational research; and 2) PhDs (or MD/PhDs) from appropriate basic and applied science fields, including population genetics molecular and cellular neurobiology, cognitive and systems neuroscience, genetic epidemiology, and physiological psychology. We have been fortunate to fill all available slots with excellent Fellows; three behavioral health care professionals and one basic/translational PhD have completed our program. Additionally, PhD and MD/PhD students who have taken our didactic survey course for credit offer recruitment opportunities for future years. For each trainee, this program includes formal course studies, a series of seminars given by the program faculty, rotation in several laboratories if appropriate at the beginning of the program, and intensive mentored training in their chosen laboratory. Dual clinic/basic mentorship is offered when appropriate. All fellows take the introductory course of the University Clinical Research Training Program, and participate in appropriate graduate courses offered by the Committee on Neurobiology, and the Departments of Psychiatry, Statistics, Health Studies, Psychology and Human Genetics. To foster interactions among the fellows and mentors, trainees give annual seminars and have an opportunity to present their accomplishments at the annual University of Chicago Neuroscience Day. Based on the successes of this program during its initial training period, we request renewal of the T32 grant with increase of the number of Fellowship slots per year from two to three.