Time-resolved MR methods for analysis of contrast and flow velocity in aneurysms

描述(申请人提供)：该项目旨在开发新的磁共振成像能力，以描绘颅内动脉瘤的解剖结构，并阐明这些实体内的血流动力学。该项目的成功完成将带来更强大、可靠和省时的磁共振成像方法，用于获取高分辨率3D血管成像和血管系统内的全7维血流测量。这将创造一种系统和系统的方法来确定颅内动脉瘤的解剖和功能，并将为临床医生制定治疗这些疾病的策略提供重要的新指导。因此，该项目的具体目标是：1)使用具有一定复杂性的流动模体来确定最合适的成像方法，以利用当前MR硬件和软件的全部能力来捕捉速度场上的时间分辨信息并评估流动管腔。2)我们的目标是开发和评估用于显示、后处理和分析来自不同时间点和模式的几何和高维血流动力学数据的工具；以及3)在患者研究中测试AIMS 1和2中开发的最佳技术，并评估随着时间的推移监测解剖和生理变化的能力。目前获取磁共振血管成像和速度测定的方法是在临床环境下开发的，在人体研究中，很难进行系统的和重复的研究。这些发展也缺乏真正的黄金标准，磁共振测量与黄金标准技术之间的比较通常是定性的。复制体内血流状态的患者衍生模型将允许确定当前方法的局限性，并允许选择最合适的方法。可与作用于动脉瘤中这些位置的血流动力相联系的结构变化位置的准确地图将提供信息，将提供对特定患者的动脉瘤疾病进展的洞察。与公众健康相关：这项建议旨在开发磁共振方法来评估脑内动脉瘤的结构，并测量这些动脉瘤内的血液流动模式。在这些地区，一种强大而可靠的非侵入性评估结构和功能的方法的可用性将使临床医生能够有效地评估患有这些疾病的患者，避免他们相关的动脉插管风险。此外，能够非侵入性地确定颅内动脉瘤的血流模式，应该能够为导致一些动脉瘤保持稳定、另一些动脉瘤增大、导致严重症状或破裂的潜在生理学提供新的见解，并极有可能造成毁灭性的脑损伤或死亡。

DESCRIPTION (provided by applicant): This project is aimed at developing new MR imaging capabilities for depicting the anatomy of intracranial aneurysms, and to elucidate the hemodynamics within these entities. Successful completion of this project will lead to more robust, reliable and time-efficient MRI methods for acquiring high resolution 3D angiograms and fully 7D flow measurements within the vasculature. This will create a systematic and methodical approach to the determination of anatomy and function in intracranial aneurysms and will provide important new guidance to clinicians as they develop strategies to treat these disorders. The specific aims of this project are therefore: 1) to use flow phantoms with a range of complexity to determine the most suitable imaging approach for capturing time-resolved information on velocity fields and for evaluating the flow lumen, using the full capabilities of current MR hardware and software. 2) We aim to develop and evaluate tools for display, post-processing and analysis of geometric and high dimensional, hemodynamic data from different time points and modalities; and 3) Test the optimal techniques developed in Aims 1 and 2 in patient studies, and evaluate the ability to monitor changes in anatomy and physiology over time. Current methods for acquiring MR angiography and velocity determination have been developed in the clinical setting on human studies where it is difficult to perform systematic and repeated studies. Those developments also lack a true gold standard and comparisons between MR measurements and gold standard techniques have typically been qualitative. Patient-derived models that replicate in vivo flow conditions will permit the determination of the limits of current methods, and allow for selection of the most suitable approach. Accurate maps of locations of structural changes that can be linked to the hemodynamic forces acting at those locations in aneurysms will provide information that will provide an insight on the progression of aneurysmal disease on a patient-specific basis. Relevance to public health: This proposal aims to develop MR methods for assessing the structure of aneurysms in the brain and for measuring blood flow patterns within those aneurysms. The availability of a robust and reliable method for non-invasively assessing structure and function in these territories will permit clinicians to effectively evaluate patients with these diseases, sparing them the associated risks of arterial catheterization. In addition, the ability to non-invasively determine blood flow patterns in intracranial aneurysms should provide new insights into the underlying physiology that causes some aneurysms to remain stable, and others to grow, resulting in profound symptoms or rupture with a high likelihood of devastating cerebral injury or death.