UCLA Center for AIDS Research (CFAR)

描述(由申请人提供)：此申请构成了加州大学洛杉矶分校(UCLA)对艾滋病研究中心(CFAR)拨款的续签。这笔赠款将资助加州大学洛杉矶分校CFAR在加州大学洛杉矶分校艾滋病研究所内开展的活动和计划。加州大学洛杉矶分校CFAR成立于1988年，艾滋病研究所成立于1992年，负责协调大学及其七家附属教学医院的所有艾滋病研究、临床和教育活动。艾滋病研究所和CFAR的整体组织在2005年进行了重组，以便更有效率和有效地管理在过去五年中增长了30%的教职员工，以及自我们上次提交续签申请以来适用于CFAR的补助金增加了50%。此次续签申请包括CFAR核心服务和活动，旨在通过基础、临床和行为科学促进对艾滋病毒/艾滋病的了解。加州大学洛杉矶分校CFAR的总体使命是在不同学科之间创造协同效应，从而在理解、预防和治疗艾滋病毒感染方面取得重大突破--特别强调高价值的跨学科合作。加州大学洛杉矶分校的CFAR由200多名教职员工组成，他们负责250多个研究项目，几乎涵盖了艾滋病毒/艾滋病生物学、临床研究和行为科学的所有方面。加州大学洛杉矶分校在艾滋病研究、教育和教学以及临床项目方面一直名列前茅。洛杉矶市是艾滋病流行的主要震中，也是美国文化最多元化的地区之一，我们的项目旨在接触到这些不同的社区。我们尤其感到自豪的是，近年来招募到我们临床试验中的患者中有50%是少数族裔社区的成员。CFAR的作用是通过支持科学和行政核心设施，并为极具价值的合作研究项目提供种子赠款，促进大学内外的合作和建立联系。请求提供支持的第一年，即2008年1月至2008年12月的行动计划摘要如下：CFAR计划继续支持由上一次CFAR赠款资助的八个核心：行政核心、发展核心、病毒学/BSL3组织培养核心、细胞计数核心、鼠/人类嵌合体核心、基因和细胞治疗核心、粘膜免疫学核心和生物统计学核心。根据不断变化的流行病学、需求评估、战略规划和修订的短期和长期目标，取消了两个核心，增加了一个临床研究促进核心和一个咨询核心。 核心A：行政核心(Zack，J.) 核心A描述(由申请者提供)：加州大学洛杉矶分校CFAR的行政核心将提供基础设施支持，为加州大学洛杉矶分校所有与艾滋病相关的研究和项目增加价值。行政核心负责监督加州大学洛杉矶分校CFAR的所有业务和治理方面。加州大学洛杉矶分校CFAR和艾滋病研究所的联合管理为CFAR提供以下形式的支持：财政管理和赠款管理，设备和用品的采购，短期和长期规划，对CFAR研讨会、座谈会和智库的行政支持(包括财务、编辑、平面设计和后勤支持)，为科学家和外行制定教育方案，校园内和社区外展活动，对种子赠款和奖学金审查的行政支持，遵守加州大学洛杉矶分校、加州大学和NIH的所有要求，营销和筹款，回应信息和援助请求(来自NIH，我们的同事和合作者，(来自媒体和公众)，并监督CFAR的所有日常活动。管理核心将通过可访问、精简和响应的管理操作，为所有CFAR项目提供高效、有效的管理。行政核心由CFAR的首席调查员Jerome Zack博士和CFAR的共同PI In/In Chen博士共同监督，他也是加州大学洛杉矶分校艾滋病研究所的主任。这一核心的具体目标是：目标1.项目发展：通过灵活和反应迅速的管理结构，制定、实施和协调项目，以支持加州大学洛杉矶分校CFAR的广泛研究活动，旨在最大限度地获得信息和援助，加强沟通和鼓励合作。目标2.新的调查员开发：通过特定的机制，促进所有加州大学洛杉矶分校艾滋病研究人员的工作，特别是初级、新手和少数族裔调查人员的工作，例如导师计划和IRB申请、人类受试者招聘、数据分析和拨款撰写方面的援助，以减少时间、成本和努力。目的3.企业事务管理：通过资助行政服务和全面协调研究活动、智囊团、种子赠款审查和CFAR的其他活动，为艾滋病研究提供基础设施。

DESCRIPTION (provided by applicant): This application constitutes a renewal on the part of the University of California/Los Angeles (UCLA) for a Center for AIDS Research (CFAR) grant. This grant will fund activities and programs conducted by the UCLA CFAR within the UCLA AIDS Institute. The UCLA CFAR was set up in 1988, and the AIDS Institute was established in 1992 to coordinate all AIDS research, clinical and educational activities at the University and its seven affiliated teaching hospitals under one central administration. The overall organization of the AIDS Institute and the CFAR was restructured in 2005, in order to more efficiently and effectively manage a faculty that has grown by 30% in the last five years and CFAR-applicable grants that have risen by 50% since we submitted our last renewal application. This renewal application includes CFAR core services and activities that are designed to advance knowledge of HIV/AIDS through the basic, clinical, and behavioral sciences. The overall mission of the UCLA CFAR is to create synergies among diverse disciplines that result in significant breakthroughs in the understanding, prevention and treatment of HIV infection-with particular emphasis on high-value cross-disciplinary collaborations. The UCLA CFAR consists of more than 200 faculty investigators who are responsible for more than 250 research projects that encompass virtually all aspects of HIV/AIDS biology, clinical studies, and behavioral science. UCLA has consistently been ranked among the top institutions for excellence in AIDS research, education and teaching, and clinical programs. Metropolitan Los Angeles is a major epicenter for the AIDS epidemic and one of the most culturally diverse regions in the nation, and our programs are designed to reach out to these diverse communities. We are particularly proud that 50% of the patients recruited into our clinical trials in recent years are members of minority communities. The role of the CFAR is to foster collaboration and build linkages both within and outside the university, through support of scientific and administrative core facilities, and the provision of seed grant funding for highly meritorious collaborative research projects. The action plan for the first year of requested support, January 2008 to December 2008, is summarized as follows: The CFAR plans to continue supporting eight of the cores funded by the previous CFAR grant: Administrative Core, Developmental Core, Virology/BSL3 Tissue Culture Core, Cytometry Core, Mouse/Human Chimera Core, Gene and Cellular Therapy Core, Mucosal Immunology Core, and the Biostatistics Core. Based upon changing epidemiology, needs assessments, strategic planning and revised short- and long-term goals, two cores were eliminated and a Clinical Research Facilitation Core and a Consultation Core are added. CORE A: Administrative Core (Zack, J.) CORE A DESCRIPTION (provided by applicant): The Administrative Core of the UCLA CFAR will provide infrastructure support that adds value to all AIDS-related research and programs at UCLA. The Administrative Core is responsible for overseeing all operational and governance aspects of the UCLA CFAR. The joint administration of the UCLA CFAR and the AIDS Institute provides the following forms of support for the CFAR: fiscal administration and grants management, procurement of equipment and supplies, short- and long-range planning, administrative support for CFAR symposia, colloquia, and think tanks (including financial, editorial, graphic-design, and logistical support), development of educational programs for scientists and laypersons, on-campus and community-based outreach activities, administrative support for seed grant and fellowship reviews, compliance with all UCLA, University of California and NIH requirements, marketing and fund-raising, respond to requests for information and assistance (from the NIH, from our colleagues and collaborators, from the press and public), and supervision of all of the day-to-day activities of the CFAR. The Administrative Core will provide efficient, effective management of all CFAR programs through an accessible, streamlined and responsive administrative operation. The Administrative Core is overseen jointly by the Principal Investigator of the CFAR, Dr. Jerome Zack, and the Co-Pi of the CFAR, Dr. In/in Chen, who is also the Director of the UCLA AIDS Institute. The specific aims of this Core are: Aim 1. Program Development: Develop, implement and coordinate programs that support the wide-ranging research activities of the UCLA CFAR through a flexible and responsive administrative structure designed to maximize access to information and assistance, to enhance communication and to encourage collaboration. Aim 2. New Investigator Development: Facilitate the work of all UCLA AIDS researchers, but particularly junior, new and minority investigators, through specific mechanisms, such as mentorship programs and assistance with IRB applications, human-subject recruitment, data analysis, and grant writing, that reduce time, costs, and effort. Aim 3. Business Affairs Administration: To provide an infrastructure dedicated to AIDS research through funding of administrative services and overall coordination of research activities, think tanks, seed grant reviews and other activities of the CFAR.