CIRCUIT ANALYSIS OF PFC AND MTL INTERACTIONS IN MONKEYS

项目总结(见说明)： 这个项目解决了使用非人类灵长类动物模型如何形成记忆的功能电路的作用。尽管有大量证据表明前额叶(PFC)和内侧颞叶(MTL)对正常记忆至关重要，但对于了解这两个系统是如何相互作用的实验努力却非常少，部分原因是神经生理学研究 主要集中在PFC或MTL上。因此，我们对它们的许多了解都是基于不同训练历史的不同动物之间的比较，通常是基于不同的任务，和/或不同的经验水平。这混淆了它们的比较，并排除了对其活动的准确计时的检查，从而深入了解网络属性和信号流。我们的目标是 对PFC和MTL有完整的理解。我们将通过同时从PFC和MTL的多个亚区的多个电极记录来实现这一点，同时猴子形成和回忆新的上下文引导的联想记忆，并根据这些记忆进行推理。通过比较记忆形成和回忆的相对神经潜伏期，我们将确定记忆是在哪里形成的，它们是如何回忆的，以及与记忆相关的信号如何在PFC和MTL之间流动。

PROJECT SUMMARY (See instructions): This project addresses the role of functional circuitry of how memories are formed using a non-human primate model. Despite the great deal of evidence that both the prefrontal cortex (PFC) and medial temporal lobe (MTL) are critical for normal memory, there has been remarkably little experimental effort toward understanding how these two systems interact This is, in part, because neurophysiological studies have largely focused on either the PFC or MTL individually. As a result, much of what we know about them is based on comparisons between different animals with different training histories, often on different tasks, and/or different levels of experience. This confounds their comparison and precludes examination of the precise timing of their activity that gives insight into network properties and signal flow. Our goal is a more integrated understanding of the PFC and MTL. We will accomplish this by recording simultaneously from multiple electrodes in multiple subregions of the PFC and MTL while monkeys form and recall new context guided associative memories and while they make inferences based on those memories. By comparing the relative neural latencies for memories to be formed and recalled, we will determine where memories are formed, how they are recalled, and how memory-related signals flow between the PFC and MTL.