Coping Styles as Predictors of Medication Adherence in Inner-City Adolescents Inf

描述（由申请人提供）：美国感染艾滋病毒的青少年的增加是一个重大问题，特别是在城市地区。艾滋病毒检测呈阳性的青年往往面临各种困难，因为他们挣扎着度过一生，同时又背负着高度耻辱和危及生命的疾病的负担。大多数研究调查艾滋病毒感染的青少年和年轻人的依从性发现，他们的艾滋病毒疾病的管理是他们的生活优先事项较少，不依从率从37%到70%不等。尽管存在有效的抗逆转录病毒疗法，但不遵守规定导致约一半的患者健康结果减少。这一问题对治疗提出了相当大的挑战，并导致重大的公共卫生影响。候选人是一名心理学家，专门从事与青少年和年轻人的工作，在马里兰州，巴尔的摩（UMB）谁进行了初步研究与艾滋病毒感染的青年。该奖项的培训阶段将包括五个主要活动：1）学习传染病和临床流行病学的基本原则，2）进一步发展研究设计和实施公共卫生和行为研究的技能，3）发展生物统计分析的高级技能; 4）培养负责任地进行研究的技能，以及5）完善演示，出版和授予写作的技能。研究阶段将探讨是否应对方式的内城青年感染艾滋病毒（IYH）可以预测他们的坚持护理设计和实施一项创新的研究。本研究的目的1是利用原始数据收集和分析，确定适应不良应对与IYH患者护理依从性之间的关系。目的2将探讨如何应对方式之间的IHY不同的传播方式，性别，种族，或年龄。这项拟议的研究将导致未来的临床试验，对干预措施的发展适当的，具体的艾滋病战略，以促进持续的艾滋病毒护理和药物治疗的依从性。完成该奖项后，候选人将成为一名严格的行为科学家，并能够发现公共卫生问题的解决方案。

DESCRIPTION (provided by applicant): The increase of HIV infected adolescents in the United States is a significant problem, especially in urban areas. Youth who test positive for HIV are often confronted with a variety of difficulties as they struggle to proceed through life while carrying the burden of a highly stigmatized and life-threatening illness. Most studies investigating adherence in HIV-infected adolescents and young adults have found management of their HIV disease to be a lesser of their life priorities with rates of noncompliance ranging from 37% to 70%. Despite the existence of effective antiretroviral therapy, nonadherence leads to diminished health outcomes in approximately half of the patients for whom it is prescribed. This issue presents a considerable challenge to treatment and results in significant public health implications. The candidate is a psychologist specializing in work with adolescents and young adults at the University of Maryland, Baltimore (UMB) who has conducted preliminary research with HIV-infected youth. The training phase of the award will consists of five primary activities: 1) to learn the essential principles of infectious disease and clinical epidemiology, 2) to develop further skills in study design and implementation of public health and behavioral research, 3) to develop advanced skills in biostatistical analysis; 4) to develop skills in the responsible conduct of research, and 5) to refine skills in presenting, publishing, and grant writing. The research phase will investigate whether the coping styles of inner city youth infected with HIV (IYH) can predict their adherence to care by designing and implementing an innovative study. Using primary data collection and analysis, Aim1 of this study will determine the relationship between maladaptive coping and adherence to care in IYH. Aim 2 will explore how coping styles among IHY differ according to mode of transmission, gender, ethnicity, or age. This proposed study will lead to future clinical trials on interventions of developmentally appropriate, adolescent-specific strategies to foster sustained HIV care and medication adherence. Upon completion of this award, the candidate will become a rigorous behavioral scientist informed by his clinical orientation and able to discover empirically-driven solutions to public health problems.