Vevo 2100 Imaging System (120V)

描述（由申请人提供）：犹他大学建议购买一台Vevo 2100超声/超声心动图，具有先进的多普勒功能和一流的成像分辨率，以支持其小动物成像核心。Vevo 2100将支持六个主要用户团队，他们迫切需要先进的非侵入性成像，以表征斑马鱼、啮齿动物和其他动物模型系统在遗传、药物学、环境或手术扰动后心血管系统结构和功能的缺陷。这些团队的主要用户是资金充足且富有成效的心血管研究者，他们一直处于小动物成像的前沿。除了为主要用户提供新的技术水平外，此次购买还将使犹他大学的研究人员能够将制造商不再生产的旧Vevo 660捐赠给核心实验室。这将大大增加整个大学的“次要用户”获得超声心动图/超声成像的机会，这些用户迫切需要管理复杂的遗传杂交菌群或进行筛查成像以调查其模型中是否存在缺陷。我们预计，随着时间的推移，这些小用户中的许多人将迅速成长为大用户。在准备工作中，犹他大学已经投入了20多万美元来支持在小动物成像核心中增加超声心动图/超声技术，以补充其目前的MRI， CT和PET成像能力。这些资金是一项初始投资，将用于支付技术人员两年多的工资和福利、用品和设备维修费用。综上所述，犹他大学将使用NIH的设备请求，为其所有研究人员大幅改进和扩展小动物成像。

DESCRIPTION (provided by applicant): The University of Utah proposes to purchase a Vevo 2100 Ultrasound/Echocardiography with advanced capabilities in Doppler and the premier imaging resolution to support it Small Animal Imaging core. The Vevo 2100 will support six teams of major users who are in immediate need of advanced non-invasive imaging to characterize defects in the structure and function of the cardiovascular system in zebrafish, rodents and other animal model systems following genetic, pharmacologic, environmental or surgical perturbations. These teams of major users are well-funded and productive cardiovascular investigators who have been at the forefront of small animal imaging. In addition to providing a new level of technology to the major users, the purchase will enable investigators at the University of Utah to donate the older Vevo 660, which is no longer in production by the manufacturers, to the core laboratory. This will greatly increase access to echocardiography/ ultrasound imaging available for "minor users" throughout the University who have an immediate need to manage colonies of complex genetic crosses or to perform screening imaging to investigate whether defects exist in their models. We envision that with time many of these minor users will graduate quickly to become major users. In preparation the University of Utah has committed over $200,000 to support the addition of echocardiography/ultrasound technology to the Small Animal Imaging core complementing its current MRI, CT and PET imaging capabilities. These funds are an initial investment that will cover technician's salary and benefits, supplies, maintenance of equipment for over two years. In summary, the University of Utah will use this equipment request to the NIH to substantially improve and expand small animal imaging for all of its investigators. PUBLIC HEALTH RELEVANCE: The request for a high-resolution ultrasound/echocardiography system, Vevo 2100, will permit imaging of organs in zebrafish, mice and other small animals. This equipment will lead to a better understanding of how genetic, pharmacologic, environmental, and surgical alterations affect the cardiovascular structure and function in model organism