UW-Madison Small Animal PET: High Resolution Large Bore Tomograph

描述（由申请人提供）：正电子发射断层扫描（PET）用于人类疾病动物模型中潜在治疗方法的体内纵向研究。此外，小动物PET允许研究其他成像方式无法实现的基本生物过程。随着高分辨率专用小动物扫描仪的出现，该领域在过去几年中迅速发展。在威斯康星大学麦迪逊分校，小动物PET已被广泛用于各种研究。威斯康星大学是哈洛生物心理学中心、威斯康星国家灵长类动物研究中心和医学与公共卫生学院的猕猴群的所在地，20世纪90年代初，麦迪逊大学在ECAT 931人体扫描仪上进行的恒河猴大脑PET研究是文献中最早的研究之一。2002年8月，华盛顿大学获得了一台微型pet P4，用于获取1859次动物扫描，包括1515次恒河猴脑部扫描（截至2009年12月31日）。为西门子医疗解决方案美国公司（Knoxville， TN）制造的微型PET Focus 220小动物正电子发射断层扫描（PET）扫描仪申请资金。Focus 220提供了改进的空间分辨率（1.4 mm FWHM）和灵敏度（4%）以及大视野（19厘米横轴和7.6厘米轴向）。这使得用更少的示踪剂质量对猕猴大脑进行更详细的成像，以及同时对多只大鼠或小鼠进行成像。在此重新提交中，我们注意到所要求的仪器对于确保继续进行NIH资助的研究的能力至关重要。供应商西门子在2009年7月正式通知，由于缺乏可用的替换组件，P4的支持日期将于2010年7月1日结束。这增加了在不久的将来失去使用现有工具的可能性。

DESCRIPTION (provided by applicant): Positron emission tomography (PET) is used for in vivo longitudinal studies of potential therapies in animal models of human disease. Small animal PET moreover permits studies of fundamental biological processes that are not possible with other imaging modalities. With the advent of high resolution dedicated small animal scanners the field has grown rapidly in the last few years. Small animal PET has been used in a wide variety of studies at UW-Madison. UW is home to macaque colonies at the Harlow Center for Biological Psychology, the Wiconsin National Primate Research Center, and the School of Medicine and Public Health, and rhesus brain PET studies performed at Madison in the early 1990s on the ECAT 931 human scanner are among the earliest in the literature. In August 2002 UW acquired a microPET P4, which has been used to acquire 1859 animal scans, including 1515 rhesus brain scans (as of 12/31/2009). Funding is requested for a microPET Focus 220 small animal positron emission tomography (PET) scanner built by Siemens Medical Solutions USA (Knoxville, TN). The Focus 220 provides improved spatial resolution (1.4 mm FWHM) and sensitivity (4%) along with a large field of view (19 cm transaxial and 7.6cm axial). This permits more detailed imaging of macaque brain with reduced tracer mass as well as simultaneous imaging of multiple rats or mice. In this resubmission, we note that the requested instrument is essential to ensure the continued capability to carry out NIH funded research. The vendor, Siemens, gave formal notification in July of 2009 that the end of support date for the P4 will be July 1, 2010 due to lack of availability of replacement components. This raises the possibility of losing use of the existing instrument in the near future. PUBLIC HEALTH RELEVANCE: Funding is requested for a small animal positron emission tomography (PET) scanner to replace existing equipment. This equipment will be used for longitudinal in vivo studies of animal models of human pathologies and imaging of fundamental biological processes. This will allow the UWMadison PET imaging program to continue to accommodate the increasing number of studies of pathologies such as mood disorders, fetal alcohol exposure, multiple sclerosis, and Parkinson's disease.