ZINC STATUS IN INFANTS WITH SICKLE CELL DISEASE: AN EXAMINATION

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 摘要 背景：镰状细胞病（SCD）的大龄儿童和成人生长障碍是公认的。 虽然生长延迟的原因可能是多因素的，但营养状况不良是最广泛的牵连。 锌缺乏被认为是关键。几项研究表明，在年龄较大的儿童和成人SCD之间的生长延迟和身体成分的改变和缺锌直接相关。然而，尚未对患有SCD的婴儿进行研究。目前尚不清楚生长迟缓是否从婴儿期开始开始，以及锌缺乏是否起作用。 本研究将评估锌状态对HbSS（纯合子SS疾病）婴儿早期生长和身体组成的影响。 假设：锌缺乏（定义为中性粒细胞锌5th %）。 将比较两组的平均锌水平。 将使用学生t检验来检验生长不良婴儿与正常生长婴儿之间的平均锌水平差异。 I. 假设 1. 锌缺乏（定义为中性粒细胞锌42 μ g/ 1010个细胞）与HbSS婴儿的生长不良相关。 具体来说，我们假设生长不良婴儿的平均锌水平将比正常生长的婴儿低至少10%。 2. HbSS婴儿的生长参数（体重或身长）将小于未受影响的健康婴儿。 具体而言，我们假设至少50%的HbSS婴儿的生长参数低于第5百分位数。 二. 具体目标 主要目的：研究镰状细胞病（HbSS）（纯合子SS病）婴儿生长不良与锌缺乏之间的关系。 次要目的：确定HbSS婴儿中生长迟缓的发生率。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. ABSTRACT Background: Growth failure in older children and adults with Sickle Cell Disease (SCD) is well established. Although the causes of growth delay are likely multifactorial, poor nutritional status has been most widely implicated. Zinc deficiency is thought to be pivotal. Several studies show a direct correlation in older children and adults with SCD between growth delay and alteration in body composition and zinc deficiency. However, infants with SCD have not been studied. It is unclear if the growth delays begin in infancy and whether zinc deficiency plays a role. This study will evaluate the effects of zinc status on early growth and body composition in infants with HbSS, homozygous SS disease. Hypothesis: Zinc deficiency (defined as neutrophil zinc 5th %). The mean zinc levels of the two groups will be compared. A students t test will be used to test the difference in the mean zinc levels between infants with poor growth compared to those with normal growth. I. HYPOTHESIS 1. Zinc deficiency (defined as neutrophil zinc 42 ¿g/ 1010 cells) will be associated with poor growth in infants with HbSS. Specifically, we hypothesize that mean zinc levels in poorly growing infants will be at least 10% below that of normally growing infants. 2. Growth parameters (weight or length) of infants with HbSS will be less than those of unaffected healthy infants. Specifically, we hypothesize that growth parameters will be below the 5th percentile in at least 50% of infants with HbSS. II. SPECIFIC AIMS Primary Aim: To examine the association between poor growth and zinc deficiency in infants with Sickle Cell Disease, HbSS (homozygous SS disease). Secondary Aim: To establish the incidence of growth delay among infants with HbSS.