Antimicrobial catheter

描述（由申请人提供）：我们建议开发一种新的血管内导管，以减少导管相关血流感染的发生。仅在美国，每年估计有25万例中心静脉导管血流感染（BSI）发生在医院。每种感染的死亡率估计为12% - 25%，每一次感染给卫生保健系统增加的费用约为25，000美元。每年照顾脑损伤患者的估计费用从2.96亿美元到23亿美元不等。因此，BSI的经济和社会成本是巨大的，并且需要一种可以降低感染风险的新导管。我们建议开发一种新的导管，使用脉冲表面加热来防止细菌生长和粘附。我们的概念使用激光，可以有效地耦合到导管壁中，以精确加热外表面上使用热致变色材料的薄吸收层。使用热致变色材料可以在预选的转变温度下快速改变其吸收特性，从而允许精确控制峰值温度。这种导管设计的优点是，它消除了对导管上的抗菌/抗生素涂层的需要，这些涂层最终可能导致耐药细菌。拟议研究的三个关键目标是：1）设计和建造原型光加热导管（LHC）和激光控制系统，2）对LHC原型进行实验室测试，以验证均匀加热和热致变色颜料的温度限制功效3）进行体外细菌测试，以验证LHC原型的抗菌性能。一种可以降低感染风险的新型导管的全球市场超过2亿美元，并有可能为医疗保健系统节省数十亿美元。成功完成拟议的研究将产生一个导管和系统设计，可以立即在动物试验中进行测试。 公共卫生相关性：仅在美国，每年估计有25万例中心静脉导管血流感染发生在医院。我们建议开发一种新的导管，使用脉冲表面加热来防止细菌生长和粘附。该导管在热变色层中使用激光吸收，以安全地加热导管表面并杀死细菌。

DESCRIPTION (provided by applicant): We propose to develop a new intravascular catheter that reduces the occurrence of catheter related blood stream infections. In the United States alone an estimated 250,000 cases of central venous catheter bloodstream infections (BSI) occur in hospitals each year. The mortality attributable to each infection is estimated to be 12% - 25% and the increased cost to the health- care system is approximately $25,000 per episode. The estimated annual cost of caring for patients with BSI ranges from $296 million to $2.3 billion. Therefore, the economical and social cost of BSI is substantial and a need exists for a new catheter that can reduce the risk of infection. We propose to develop a new catheter that uses pulsed surface heating to prevent bacterial growth and adhesion. Our concept uses laser light that can be effectively coupled into the catheter wall to accurately heat a thin absorbing layer on the outer surface that uses thermochromic material. The use of a thermochromic material which can quickly change it's absorption properties at a preselected transition temperature allows for accurate control of the peak temperature. The advantage of this catheter design is that it eliminates the need for antimicrobial/antibiotic coatings on catheters which can ultimately lead to drug resistant bacteria. The three key aims of the proposed research are: 1) Design and build a prototype light heated catheter (LHC) and laser control system, 2) Perform laboratory testing of the LHC prototype to verify uniform heating and the temperature limiting efficacy of thermochromic pigments 3) Perform in-vitro bacterial testing to validate the antimicrobial properties of the LHC prototype. The worldwide market for a new catheter that can reduce the infection risk exceeds $200 Million and has the potential to save the health care system billions of dollars. Successful completion of the proposed research will yield a catheter and system design that can immediately be tested in animal trials. PUBLIC HEALTH RELEVANCE: In the United States alone an estimated 250,000 cases of central venous catheter bloodstream infections occur in hospitals each year. We propose to develop a new catheter that uses pulsed surface heating to prevent bacterial growth and adhesion. The catheter uses laser absorption in a thermochromic layer to safely heat the catheter surface and kill bacteria.