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中文摘要
翻译
核心B将有三个具体目标。 具体目标1是从MCG Health Inc.接受肺叶切除或肺切除的受试者中获取、鉴定和繁殖人肺微血管内皮细胞;将所述细胞提供给所有四个项目的研究人员,用于渗透性、分析和其他分子研究。 具体目标2是建立并向所有四个项目提供气管内诱导的ALI小鼠 革兰氏阳性或革兰氏阴性细菌产品的滴注。 特异靶3:活体肺毛细血管通透性(伊文氏蓝染色法) 四个项目各自设计的研究的测量和肺功能(呼吸道力学)测量。
英文摘要
Core B will have three specific aims. Specific Aim 1 is to harvest, characterize and propagate human lung microvascular endothelial cells from subjects undergoing lobectomy or pneumonectomy at MCG Health Inc.; provide said cells to investigators in all four projects for permeability, analytical and other molecular studies. Specific Aim 2 is to create and supply to all four projects mice with ALI induced by intra-tracheal instillation of gram positive or gram negative bacterial products. Specific Aim 3 is to perform in vivo lung capillary permeability (Evan's Blue Dye Method) measurements and lung function (airway mechanics) measurements for studies designed by each of the four projects.
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Antidotes against HCI-induced chronic lung injury
  • 批准号:
    10015581
  • 项目类别:
  • 资助金额:
    $45.88万
  • 财政年份:
    2020
  • 负责人:
    John D Catravas
  • 依托单位:
Antidotes against HCI-induced chronic lung injury
  • 批准号:
    10241958
  • 项目类别:
  • 资助金额:
    $45.28万
  • 财政年份:
    2020
  • 负责人:
    John D Catravas
  • 依托单位:
Antidotes against HCI-induced chronic lung injury
  • 批准号:
    10471329
  • 项目类别:
  • 资助金额:
    $44.0万
  • 财政年份:
    2020
  • 负责人:
    John D Catravas
  • 依托单位:
Antidotes against mustard-induced chronic lung injury
  • 批准号:
    9789315
  • 项目类别:
  • 资助金额:
    $19.38万
  • 财政年份:
    2018
  • 负责人:
    John D Catravas
  • 依托单位:
海外基金