DIABETES PREVENTION PROGRAM OUTCOMES STUDY (DPPOS)

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 DPPOS的主要目标是评估积极的DPP干预对a)糖尿病未来5-10年发展的长期影响，以及b)与糖尿病相关的微血管病变和心血管疾病的综合结果。正在测试的假设是，与以前的安慰剂组相比，持续的生活方式干预和二甲双胍都将继续分离糖尿病的发展速度，而在DPP和DPPOS期间预防或推迟糖尿病将转化为综合结果的降低和健康状况的改善。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary objective of the DPPOS is to evaluate the long-term effects of active DPP interventions on the development of a ) diabetes during a further 5-10 years of follow-up and b) composite diabetes-related microangiopathic and cardiovascular disease outcomes. The hypotheses being tested are that both the continued lifestyle intervention and metformin will provide continued separation in the rates of diabetes development, compared with the former placebo group, and that the prevention or delay of diabetes during the DPP and DPPOS will translate into reduced rates of composite outcomes and improved health status.