THE ROLE OF LACTOSYLCERAMIDE IN RENAL AGING AND DISEASE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 即使在没有明显疾病的情况下，肾功能也会随着年龄的增长而逐渐下降。衰老的肾脏暴露于肾脏应激源增加，对损伤的易感性增加，损伤后自我修复的能力降低。老年人的肾脏疾病的发病率也比年轻人更高，包括慢性肾脏疾病和终末期肾脏疾病。在老年肾脏和许多与年龄相关的肾脏疾病中，脂质代谢会发生变化，导致甘油三酯和胆固醇的有毒积累。这种脂毒性被认为是肾脏老化和疾病期间细胞凋亡、坏死和炎症水平增加的主要原因。该项目的长期目标是开发新的治疗方法，以防止在衰老过程中以及慢性和终末期肾脏疾病中肾功能的丧失。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. There is an age-associated progressive decline in renal function even in the absence of obvious disease. The aged kidney has increased exposure to renal stressors, enhanced susceptibility to injury, and decreased ability to repair itself following injury. The elderly also have an increased incidence of renal disease than young adults, including chronic kidney disease and end-stage renal disease. Lipid metabolism is altered in aged kidneys and in many age-associated kidney diseases, resulting in toxic accumulation of triglycerides and cholesterol. This lipotoxicity is thought to play a major role in the increased levels of apoptosis, necrosis, and inflammation that occur during renal aging and disease. The long-term goals of this project are to develop novel therapeutics that can prevent the loss in kidney function during aging and in chronic and end-stage renal disease.