SC COBRE: PROTEIN SCIENCE CORE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 蛋白质科学核心继续支持科布雷研究人员的活动。具体地说，它已被用于过量生产和纯化几种蛋白质，并利用圆二色谱、动态光散射和等温量热法表征它们的生物物理行为。最值得注意的是，新任科布雷研究员张永梅博士已经开始广泛使用该实验室来生产与喹诺酮类假单胞菌信号有关的几种蛋白质。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Protein Science Core has continued to support the activities of the COBRE investigators. Specifically, it has been used to over-produce and purify several proteins, and to characterize their biophysical behavior using circular dichroism, dynamic light scattering and isothermal calorimetry. Most notably, Dr. Yong-mei Zhang, who is a new COBRE Investigator, has begun to use the lab extensively for the production of several proteins involved in Pseudomonas quinolone signaling.