TYROSINASE AND HEMOCYANIN

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 酚氧化酶(POS)存在于所有生物体中，参与哺乳动物的皮肤和毛发着色，并在伤口愈合过程中启动黑化。PO基因突变或过表达可分别导致白化病或黑色素瘤。十二烷基硫酸钠可以将失活的PO和氧载体血蓝蛋白(HC)转化为具有酶活性的PO。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Phenoloxidases (POs) occur in all organisms and are involved in skin and hair coloring in mammals, and initiating melanization in wound healing. Mutation or overexpression of PO can cause albinism or melanoma, respectively. SDS can convert inactive PO and the oxygen carrier hemocyanin (Hc) into enzymatically active PO.