MICRODIFFRACTION AT THE NE-CAT BEAMLINES

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 由于我们的用户对能够对小于20-30微米的晶体进行衍射实验的需求不断增加，2007年初，资源中心在24-ID-E光束线上安装了一个微衍射设备。有了这一点，我们能够提供小至5微米的稳定X射线光束，这种光束可以根据样品的尺寸进行定制，以减少散射污染和背景。这一操作安装实现了我们的主要核心1目标之一，即在美国提供第一个这样的微衍射设备。此外，这也导致了一些独特的结构，否则是不可能的。24-ID-E光束线上的微衍射实验是如此成功和受欢迎，以至于我们的用户社区希望我们也能在我们的可调谐光束线24-ID-C上复制完全相同的能力。在我们核心合作者和HHMI调查人员(S.C.Harison、D.Eisenberg和E.Gouaux)的支持下，我们能够获得资金(向SCH提供设备赠款)，用于在24-ID-C上安装第二个MD2。2009年初，24-ID-C配备了一个MD2，与24-ID-E上的类似。虽然第一年的核心研究花在设置、调试和用户操作上，但在第二年，我们集中精力开发微衍射的实际使用方法和增强微衍射能力。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Due to increasing demand from our user community to be able carry out diffraction experiments with crystals smaller than 20-30 microns, during early 2007 the Resource implemented a microdiffraction facility at the 24-ID-E beamline. With that, we were able to deliver stable X-ray beams as small as 5 microns, which can be tailored to dimensions of the samples in order to reduce scattering contamination and backgrounds. This operating installation resulted in meeting one of our major Core 1 goals of providing the first such microdiffraction facility in the US. Also, this has resulted in some unique structures, which otherwise would not have been possible. The microdiffraction experiments at 24-ID-E beam-line were so successful and popular that our user community wanted us to replicate the exact same capability on our tunable beamline 24-ID-C as well. With the support of our core collaborators and HHMI investigators (S.C. Harrison, D. Eisenberg and E. Gouaux), we were able to secure funding (equipment grant to SCH) for a second MD2 for installation on 24-ID-C. During early 2009, 24-ID-C was outfitted with an MD2, similar to the one on 24-ID-E. While the first year of Core 1 research was spent on set-up, commissioning and user operations, during the second year we concentrated on developing methods for practical use of microdiffraction and enhancement of the microdiffraction capability.