BRANCHED CHAIN AMINO ACID TRANSAMINASE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 支链氨基酸转氨酶(ILVE)是细菌合成此类氨基酸的生物合成途径的一部分。这些是人类饮食中必不可少的氨基酸，使细菌转氨酶成为这一独特细菌途径的良好药物靶点。结核病(TB)ILVE蛋白已经结晶，希望对这种酶的结构理解将导致潜在的治疗这种疾病的新疗法。晶体结构将补充我们对这种酶的动力学工作，并通过了解这一重要的细菌生物合成途径的这一关键成分。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Branched-Chain-Amino-Acid Transaminase enzymes (IlvE) are part of the bacterial biosynthetic pathway for the denovo synthesis of this class of amino acids. These are dietary essential amino acids for humans, making the bacterial transaminase a good drug target for this unique bacterial pathway. The tuberculosis (Tb) Ilve protein has been crystallized in hopes that the structural understanding of this enzyme will lead to potential new therapies for the treatment of this disease. The crystal strucuture will complement our kinetic work on this enzyme and a through understanding of this key component of this essential bacterial biosynthetic pathway.