MATURATION OF HIGH-DENSITY LIPOPROTEINS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 高密度脂蛋白(http://www.ks.uiuc.edu/Research/Lipoproteins/)是一种蛋白质-脂质组合体，参与 胆固醇从外周组织到肝脏的运输以进行降解。高密度脂蛋白通常被称为“好胆固醇”。 它在清除组织和血管中多余的胆固醇方面的作用。高密度脂蛋白水平一直低于平均水平 与增加患冠心病的风险有关。高密度脂蛋白的产生、转化和降解是 受反向胆固醇运输途径的调节。载脂蛋白A-I(apo A-I)是 高密度脂蛋白，最初形成无脂/差的高密度脂蛋白颗粒。无脂/贫高密度脂蛋白颗粒中胆固醇和脂类的掺入 导致结构变化，形成盘状脂蛋白颗粒。胆固醇和脂类的持续外流以及 胆固醇的酯化导致盘状颗粒转变为成熟的球形颗粒，这 将胆固醇输送到肝脏[1]。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. High-density lipoproteins (HDL) (http://www.ks.uiuc.edu/Research/Lipoproteins/) are protein-lipid assemblies involved in the transport of cholesterol from peripheral tissues to the liver for degradation. HDL is often called "good cholesterol" due to its role in removing excess cholesterol from tissues and blood vessels. Lower than average levels of HDL have been implicated in an increased risk of coronary heart disease. The production, transformation, and degradation of HDL is regulated by the reverse cholesterol transport pathway. Apolipoprotein A-I (apo A-I), the primary protein component of HDL, initially forms lipid-free/poor HDL particles. The incorporation of cholesterol and lipids into lipid-free/poor HDL particles causes a structural change, forming discoidal lipoprotein particles. Continued efflux of cholesterol and lipids as well as the esterification of cholesterol results in the transformation of the discoidal particles into mature spherical particles, which transport the cholesterol to the liver [1].