EXPERIMENTAL MODEL FOR CHORIOAMNIIONITIS AND PRETERM LABOR

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 早产仍然是一个重大的经济和公共卫生负担，而且发病率还在上升。我们的目标是建立一个非人类灵长类动物(NHP)的牵张诱导早产(PTL)模型，以阐明机械拉伸是如何通过子宫肌层和胎膜感知的。子宫拉伸通常是多胎妊娠中PTL发病的原因，在过去十年中，PTL占早产儿的15%，占早产率增加的50%。多胎妊娠的妇女可以通过早期超声识别，使她们成为预防干预的理想目标群体。统一的假设是，一种新的子宫拉伸的NHP模型将模拟人类拉伸诱导的PTL，并定义这种类型PTL的发病机制和后续事件。以前，我们已经确定了在体外牵拉诱导分娩相关基因表达的细胞内机制，现在需要建立一个动物模型来测试潜在的治疗干预措施。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Preterm birth remains a significant economic and public health burden and the incidence is rising. Our objective is to develop a nonhuman primate (NHP) model of stretch-induced preterm labor (PTL) to elucidate how mechanical stretch is sensed by the myometrium and fetal membranes. Uterine stretch is often responsible for the onset of PTL in multiple gestation, which accounts for 15% of preterm births and 50% of the increase in preterm birth rates over the last decade. Women with a multiple gestation can be identified by early ultrasound making them an ideal group to target for prophylactic interventions. The unifying hypothesis is that a novel NHP model of uterine stretch will emulate human stretch-induced PTL and define the initiating and subsequent events in the pathogenesis of this type of PTL. Previously, we have defined intracellular mechanisms responsible for stretch-induced expression of labor-associated genes in vitro and now need to establish an animal model in which to test potential therapeutic interventions.