Administrative

虽然高效抗逆转录病毒疗法仍然是艾滋病毒/艾滋病研究的重大成就之一，并导致发病率和死亡率大幅下降，但它需要终身坚持，并与重大毒性和成本有关。单靠抗逆转录病毒疗法无法根除艾滋病毒;因此，需要采取新的方法来了解艾滋病毒在治疗期间持续存在的机制，并确定可以从感染者体内根除病毒的干预措施。我们已经建立了一个国际合作实验室的学术和行业调查谁拥有长期和成功的跟踪 与他人合作构思、实施和完成与表征病毒持久性和探索根除病毒的干预措施相关的创新研究项目的记录。行政核心将确保统一合作实验室的科学愿景在所有项目和核心中得到实施，并反映在所产生的研究中。该核心的功能是特别重要的，因为我们的合作实验室整合了研究人员在几个国际地点以及美国境内的多个机构。行政核心的具体目标是：1）提供一个组织和方案结构; 2）提供组织和财务监督和规划，确定优先事项，并建立决策程序; 3）确保有效的数据、信息和资源共享; 4）建立一个扩大现有合作实验室的机制。这些目标将通过采用一系列技术来支持指导委员会、执行委员会、科学咨询小组和所有各方之间定期、有效的沟通和信息共享来实现。 参加合作实验室。这里提出的方法将最大限度地提高合作实验室所有成员的生产性参与，并提供一个平台，在项目和核心内收集的数据将为合作实验室其他组成部分的活动提供信息。

While highly active antiretroviral therapy remains one of the great triumphs of HIV/AIDS research and has resulted in a significant decrease in morbidity and mortality, it requires life-long adherence and is associated with significant toxicities and cost. Antiretroviral therapy alone cannot eradicate HIV; accordingly, new approaches are required to understand the mechanisms by which HIV persists during therapy and to identify interventions that can eradicate the virus from the body of an infected person. We have established an international Collaboratory of academic and industry investigators who have a long and successful track record of collaborating with others to conceive, implement, and complete innovative research projects relevant to characterizing viral persistence and exploring interventions to eradicate the virus. The Administrative Core will ensure that the scientific vision that unifies the Collaboratory is enacted in all the projects and cores, and reflected in the research that is produced. The Core's functions are especially important because our Collaboratory integrates researchers across several international locations as well as multiple institutions within the United States. The specific aims of the Administrative Core are: 1) to provide an organizational and programmatic structure; 2) to provide organizational and financial oversight and planning, set priorities, and establish a decision-making process; 3) to ensure efficient data, information and resource sharing; and 4) to establish a mechanism for expanding the current Collaboratory. These aims will be achieved by employing a range of technologies to support regular, efficient communications and information sharing between the steering committee, executive committee, Scientific Advisory Panel, and all participants in the Collaboratory. The methodologies proposed here will maximize the productive participation of all members of the Collaboratory and provide a platform on which data gathered within projects and cores will inform the activities of other components of the Collaboratory.