NATIONAL HIV BEHAVIORAL SURVEILLANCE SYSTEM

描述(由申请人提供)：马里兰州卫生与精神卫生部(DHMH)，传染病和环境卫生管理局要求美国卫生与公众服务部，疾病控制和预防中心(CDC)在五年内拨款4,018,636美元，以在马里兰州巴尔的摩-汤森实施国家艾滋病毒行为监测系统(NHBS)。NHBS是一项匿名研究，重点招募三个艾滋病毒感染风险人群：男男性行为者(MSM)、注射吸毒者(IDU)和艾滋病毒感染风险增加的异性恋者(HET)。这项研究将包括使用相同访谈工具的一系列五项横断面调查，将招募上述危险人群(第一年和第四年的男男性接触者，第二年和第五年的注射吸毒者，第三年的HET)。建议的样本量为MSM和IDU人群每年至少500名参与者，HET人群每年450名参与者。拟议的研究将包括一份详细的问卷，以收集有关人口统计、性和吸毒行为、艾滋病毒检测和当地艾滋病毒使用情况的信息。 预防规划服务。调查问卷将在全国范围内标准化，并增加一些针对巴尔的摩的有限问题。这项研究还将提供艾滋病毒检测，利用FDA批准的艾滋病毒诊断测试和最近艾滋病毒血清转换的血清学测试算法(STARHS)来识别最近的感染。将为每个目标人口选择适当的抽样和招募方法，并将与疾控中心合作制定这些方法。男男性接触者招募将以场馆为基础。公共场所(如酒吧、俱乐部等)在巴尔的摩市，将随机抽样，并系统地接触男性以进行招聘。IDU和HET招聘将使用受访者驱动抽样(RDS)。最初的注射吸毒者和HET参与者将通过关键的社区线人招募，然后接受培训，以招募其风险群体的更多成员。一波又一波的吸毒者/吸毒者将招募更多的吸毒者/吸毒者。需要补充资金，以在所有五年内进行乙肝和丙型肝炎检测，在第一年招募200名使用RDS的男性到女性变性人参与者，并在第一年收集额外的血液样本进行进一步的艾滋病毒检测。NHBS将提供有价值的信息，用于衡量艾滋病毒危险行为，用于规划和确定马里兰州艾滋病毒预防活动的目标，并用于编制全国受影响最严重地区高危人群艾滋病毒危险行为的国家估计。

DESCRIPTION (provided by applicant): The Maryland Department of Health and Mental Hygiene (DHMH), Infectious Disease and Environmental Health Administration is requesting $4,018,636 over five years from the U.S. Department of Health and Human Services, Centers for Disease Control and Prevention (CDC) to implement the National HIV Behavioral Surveillance System (NHBS) in the Baltimore- Towson, Maryland metropolitan area. The NHBS is an anonymous research study which focuses on recruiting three populations at risk for HIV infection: Men who have sex with men (MSM), injection drug users (IDU), and heterosexuals at increased risk for HIV infection (HET). This study will consist of a series of five cross-sectional surveys using the same interview instrument, which will recruit each of the above risk populations (MSM in years 1 and 4, IDU in years 2 and 5, HET in year 3). The proposed sample size is an annual minimum of 500 participants for the MSM and IDU populations and 450 for the HET population. The proposed study will include a detailed questionnaire to gather information on demographics, sexual and drug use behaviors, HIV testing, and utilization of local HIV prevention program services. The questionnaire will be standardized nationally, with the addition of a limited number of questions specific to Baltimore. The study will also offer HIV testing, utilizing both FDA approved HIV diagnostic tests and the Serologic Testing Algorithm for Recent HIV Seroconversion (STARHS) for the identification of recent infections. The sampling and recruitment methodologies will be selected as appropriate for each of the target populations and will be developed in collaboration with the CDC. MSM recruitment will be venue-based. Public venues (e.g., bars, clubs, etc.) in Baltimore City will be randomly sampled and men will be systematically approached for recruitment. IDU and HET recruitment will utilize respondent driven sampling (RDS). Initial IDU and HET participants will be recruited through key community informants and then be trained to recruit additional members of their risk group. Successive waves of IDU/HET recruits will recruit additional IDUs/HETs. Supplemental funding is requested to perform hepatitis B and C testing during all five years, to recruit 200 male to female transgendered participants using RDS during the first year, and to collect additional blood specimens for further HIV testing during the first year. The NHBS will produce valuable information for measuring HIV risk behaviors for planning and targeting HIV prevention activities in Maryland, and for producing national estimates of HIV risk behaviors in high-risk populations in the most affected regions of the country.