Nutrition/Weight Loss, Exercise, Wellness Treatment for Bipolar Disorder

描述(申请人提供)：心血管疾病(CVD)是双相情感障碍发病率和死亡率的主要原因，但还没有开发出经验性验证的心理社会干预措施来管理BD中CVD的风险因素。这个以患者为导向的研究职业发展奖的目的是开发和测试综合治疗的可行性和可接受性，以减少心血管疾病风险因素，同时试验其有效性。设计的治疗方法整合了营养/减肥策略、运动干预和健康(新的TX)理论，以解决与双相情感障碍共同发生的心血管疾病的风险因素。新的TX在这三个模块中的每个模块中都包括了新的干预策略，以及修改和定制的双相情感障碍经验支持的策略。主要的假设是，新的TX将是可行的，可以被这些人群接受，并与20周内心血管疾病风险因素(即Framingham风险评分)的改善有关。探索性分析将检验治疗反应的预测因素以及新TX对情绪症状和整体功能的影响。将在以下方面寻求培训：1)人工开发和临床试验；2)饮食和运动干预和评估；以及3)用于临床试验纵向数据分析的复杂统计模型。培训和研究计划支持候选人的长期目标，即建立一个创新的、个性化治疗研究的多学科计划，以解决双相情感障碍中不成比例的心血管疾病的医疗负担，这是一个重要的公共卫生问题。这一领域的进一步研究有可能改善双相情感障碍患者的生活，减少他们治疗和管理并存心血管疾病的入院和就诊次数。 公共卫生相关性：心血管疾病是双相情感障碍患者死亡的主要原因。这项研究开发了一种治疗双相情感障碍的新的心理社会治疗方法，以改善与心血管疾病相关的危险因素，检查其可行性和可接受性，并试行其疗效。这将减少这一人群的就诊和住院人数，并有可能改善双相情感障碍症状和功能，从而影响公共卫生。

DESCRIPTION (provided by applicant): Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in bipolar disorder, yet no empirically validated psychosocial interventions to manage risk factors for CVD in BD have been developed. The purpose of this Mentored Patient-Oriented Research Career Development Award is to develop and test the feasibility and acceptability of an integrated treatment to decrease CVD risk factors, while piloting its efficacy. The designed treatment integrates theories on Nutrition/weight loss strategies, Exercise interventions, and Wellness (NEW Tx) to address risk factors for CVD that co-occur with bipolar disorder. NEW Tx includes novel intervention strategies in each of these three modules, as well as modified and tailored empirically-supported strategies for bipolar disorder. The primary hypotheses are that NEW Tx will be feasible to deliver, acceptable to this population, and associated with improvements in CVD risk factors (i.e., Framingham Risk Score) over 20 weeks. Exploratory analyses will examine predictors of treatment response and the effect of NEW Tx on mood symptoms and overall functioning. Training will be sought in: 1) manual development and clinical trials; 2) diet and exercise interventions and assessment; and 3) sophisticated statistical models for longitudinal data analysis of clinical trials. The training and research plan supports the candidate's long-term goal of establishing a multidisciplinary program of innovative, personalized treatment research that targets the disproportionate medical burden of CVD in bipolar disorder, an important public health problem. Further research in this area has the potential to improve the lives of individuals with bipolar disorder, by reducing their medical admissions and encounters for treatment and management of comorbid CVD. PUBLIC HEALTH RELEVANCE: Cardiovascular disease is the leading cause of death among individuals with bipolar disorder. This research study develops a new psychosocial treatment for bipolar disorder to improve risk factors associated with cardiovascular disease, examines its feasibility and acceptability, and pilots its efficacy. This will impact public health by reducing medical visits and hospital admissions in this population as well as by potentially improving bipolar symptoms and functioning.