FASEB SRC on Protease in Hemostasis and Vascular Biology

描述（由申请人提供）：在美国实验生物学学会联合会（FASEB）夏季研究会议项目的主持下，“止血和血管生物学中的蛋白酶”会议将得到部分支持。本次会议将是自1992年以来每两年举行一次的系列会议中的第10次会议，并计划于2011年6月12日至17日在亚利桑那州无忧无虑的FASEB夏季会议地点举行。会议的重点已经从最初致力于凝血酶的结构-功能研究发展到更广泛的蛋白酶在止血和血管生物学领域。基于蛋白酶及其受体、底物和抑制剂在止血、血管细胞信号传导、屏障功能、胚胎发育、细菌毒力/宿主防御和炎症性疾病（包括心血管疾病和神经炎症性疾病）中的作用的新见解，对这一领域的兴趣异常强烈，研究活动正在加速。这个独特的会议在蛋白酶和血管生物学领域建立了自己的地位，并享有国际声誉，因为它始终强调未发表的、前沿的基础和转化研究，这些研究人员具有不同的专业知识和广泛的人口统计学。会议定期汇集了一流的成熟研究者，杰出的年轻研究者和有天赋的学员，进行亲密，平衡，高度互动和协同的科学交流。在血管生物学中蛋白酶领域的一些最引人注目的最新成就是在以前的会议上首次公布的，学院环境也经常培养重要的新研究计划。已经同意参加的受邀演讲者和讨论领导者的名单令人印象深刻，其中包括该领域的顶级研究人员。这些与会者将提高环境的刺激性质，为所有与会者，特别是初级调查员和学员。与以往的会议一样，组织者的一个优先事项将是促进妇女和少数民族的参与，并促进青年教师、学生、博士后研究员和身体残疾人士的参加。会议目前包括一个主题演讲和9场会议，专门讨论(1)血小板活化/血栓形成的调节，(2)蛋白酶及其受体和抑制剂的生物化学和细胞生物学，(3)新型丝氨酸蛋白酶和蛋白酶与疾病耦合的机制，(4)体内fXII和fXII依赖性事件，(5)蛋白酶信号和血管生物学，(6)控制血管通透性的综合系统，(7)炎症和宿主防御中的蛋白酶，(8)蛋白酶工程与治疗；(9)蛋白酶在神经生物学中的靶点。

DESCRIPTION (provided by applicant): Partial support is requested for the "Proteases in Hemostasis and Vascular Biology" conference to be held under the auspices of the Summer Research Conference program of the Federation of American Societies for Experimental Biology (FASEB). This meeting will be the 10th in a series that has been held biennially since 1992 and is scheduled to be held at the FASEB summer conference site in Carefree, Arizona on June 12-17, 2011. The focus of the meeting has evolved from one originally devoted to structure-function studies of thrombin into a broader arena of proteases in hemostasis and vascular biology. Interest in this area has been exceptionally strong and research activity is accelerating based on new insights on the role of proteases and their receptors, substrates and inhibitors in hemostasis, vascular cell signaling, barrier function, embryonic development, bacterial virulence/host defense, and inflammatory diseases, including cardiovascular disease and neuroinflammatory disease. This unique conference has established itself in the field of proteases and vascular biology and enjoys an international reputation for consistently emphasizing unpublished, cutting-edge basic and translational research by investigators with diverse expertise and broad demographics. The meeting has routinely drawn together a powerful mix of premiere established investigators, outstanding young investigators and gifted trainees for intimate, balanced, highly-interactive and synergistic scientific exchanges. Some of the most spectacular recent achievements in the area of proteases in vascular biology were first unveiled at previous conferences and the collegial environment has routinely fostered important new research initiatives. The roster of invited speakers and discussion leaders who have already agreed to participate is impressive and include top investigators in the field. These attendees will enhance the stimulating nature of the environment for all attendees and especially junior investigators and trainees. As in past conferences, a priority of the organizers will be to promote program participation of women and minorities and facilitate attendance by junior faculty, students, postdoctoral fellows and individuals with physical disabilities. The program currently includes a keynote address and 9 sessions devoted to (1) platelet activation/regulation of thrombus formation, (2) biochemistry and cell biology of proteases and their receptors and inhibitors, (3) novel serine proteases and mechanisms coupling proteases to disease, (4) fXII- and fXI-dependent events in vivo, (5) protease signaling and vascular biology, (6) integrated systems controlling vascular permeability, (7) proteases in inflammation and host defense, (8) protease engineering and therapeutics, and (9) protease targets in neurobiology.