Pain in Sickle Cell Disease: Basic & Clinical Science Advances and Future Directi

描述（由申请人提供）：镰状细胞病患者的疼痛是一个公认的健康问题。然而，在理解和治疗镰状细胞痛方面进展甚微。一个主要的障碍是镰状细胞病和疼痛领域的研究人员之间相互作用和合作的机会有限。研讨会“镰状细胞病的疼痛：基础和临床科学进展及未来方向”的目的是向疼痛研究人员和医生介绍疾病和镰状细胞疼痛的认识，并阐明疼痛研究的科学现状。该研讨会计划作为2011年美国疼痛协会年会的附属会议，因此它将汇集镰状细胞和疼痛专家，否则他们可能没有机会进行面对面的对话。研讨会将重点介绍科学界为更好地理解镰状细胞病的神经生物学机制和适当治疗疼痛而寻求的新科学方法和新技术。本次研讨会旨在实现以下具体目标：1)介绍镰状细胞性贫血患者疼痛相关的科学进展；2)认识镰状细胞性疼痛不同动物模型的优缺点；3)讨论疼痛机制的进展与镰状细胞性疼痛研究的相关性；4)认识到镰状细胞痛作为一生中伤害性和神经性疼痛的翻译模型的潜力；5)促进镰状细胞和疼痛研究人员之间的合作；6)确定进行多站点翻译研究的潜在合作。

DESCRIPTION (provided by applicant): Pain in patients with sickle cell disease is a well recognized health problem. However, little progress has been made in understanding and treating sickle cell pain. A major barrier is limited opportunities for the interaction and collaboration among researchers from sickle cell disease and pain fields. The purpose of the Symposium, Pain in Sickle Cell Disease: Basic and Clinical Science Advances and Future Directions, is to bring the awareness of the disease and sickle cell pain to pain researchers and physicians, and to illuminate the state-of-science in pain research. The Symposium is planned as a satellite meeting of the 2011 American Pain Society Annual Meeting, so it will bring together sickle cell and pain experts who may otherwise not have an opportunity to have face-to-face dialogue. The symposium will highlight new scientific approaches and new technologies in the scientific community's quest for a better understanding of neurobiological mechanisms and proper treatment of pain in sickle cell disease. The symposium aims to achieve the following specific objective: 1) present the state-of-the-science related to pain in people with sickle cell anemia; 2) recognize the advantages and disadvantages of the different animal models of sickle cell pain; 3) discuss the relevance of advances in pain mechanisms to research in sickle cell pain; 4) recognize potential for sickle cell pain to serve as a translational model of nociceptive and neuropathic pain across the life-span; 5) foster collaborations among sickle cell and pain researchers; and 6) identify potential collaborations for conducting multi-site translational studies. PUBLIC HEALTH RELEVANCE: Limited progress has been made in characterizing and treating chronic pain in sickle cell disease. A major barrier is limited opportunities for the interaction and collaboration among researchers from sickle cell disease and pain fields. The Purpose of the Symposium, Pain in Sickle Cell Disease: Basic and Clinical Science Advances and Future Directions, is to bring the awareness of the disease and sickle cell pain to pain researchers and physicians, and to illuminate the state-of-science in pain research. A major goal of the symposium is to foster potential collaborations among researchers from various disciplines and research centers.