Fourth International Symposium on Childhood, Adolescent and Young Adult Non-Hodgk

描述（由申请人提供）：我们建议组织和进行第四届（2012年11月1日至3日）儿童，青少年和年轻成人非霍奇金淋巴瘤（NHL）（CAYA NHL）国际研讨会在纽约喜来登酒店和大厦在纽约，纽约。前两次专题讨论会分别于2003年和2006年在纽约同一地点举行，最近一次于2009年在德国的法兰克福举行。米切尔S.开罗，医学博士和阿尔弗雷德赖特，医学博士一直是主席和共同主席的所有四个国际研讨会上CAYA NHL。儿童和青少年的NHL是一种孤儿（罕见）疾病，在美国每年仅占约750-800例。然而，尽管在过去30年中，患有NHL的CAYA的总生存率（OS）有了显著改善，但用于增加我们对流行病学，基础生物学，新的转化和靶向治疗的发展和这种孤儿疾病的长期影响，以及几乎可以忽略的教育会议支持。成人NHL，一种仍然罕见但更常见的疾病（55，000/年/美国），与CAYA NHL相比，在相同的30年期间，生存率只有很小的增加，在过去得到了更多的NIH和生物制药教育会议的支持。尽管CAYA NHL的5年OS有所改善，但仍有许多未回答的问题需要未来的关键调查，这将在多学科和多国研讨会之后得到部分促进。拟议会议的主要目标（简报）：1）介绍CAYA伴BL、DLBCL、LBL和ALCL的生物学和治疗进展; 2）突出罕见组织学亚型的诊断和治疗的新进展，包括PTCL，T/NK NHL和滤泡性NHL在CAYA患者中; 3）确定CAYA NHL的基因组学，蛋白质组学和免疫表型特征; 4）表征生物学和治疗，并促进儿科和医学肿瘤学家在AYA与NHL护理中的合作; 5）讨论新的、新颖的和有针对性的治疗策略在CAYA与NHL; 6）开发体液、细胞和干细胞治疗方法在CAYA与NHL;次要目标：1）促进教育，成功和领导的年轻研究人员和研究人员在培训谁执行研究在CAYA与NHL; 2）加强与CAYA伴NHL研究者的国际交流与合作;和3）为在资源较少的社会经济环境中从事CAYA护理或研究的研究人员提供教育机会，NHL。第四届国际研讨会的结果很可能会增加我们对这种罕见疾病科学研究的基础，转化和临床状态的理解，并提供一个机会和平台，让年轻和高级多学科和多国研究人员参与国际合作研究，为后代CAYA NHL患者开发毒性更低，更具分子和免疫靶向的研究。 公共卫生相关性：这次关于儿童、青少年和年轻成人非霍奇金淋巴瘤的国际研讨会将由多学科和多国研究人员参加。该教育计划将促进该领域的新知识，促进国际合作研究，提高该专业年轻研究人员的成熟度，并弥合儿科和医学肿瘤学家治疗青少年和年轻人（AYA）与非霍奇金淋巴瘤之间的临床和科学差距。

DESCRIPTION (provided by applicant): We propose to organize and conduct the Fourth (Nov. 1-3, 2012) International Symposium on Childhood, Adolescent and Young Adult Non-Hodgkin's Lymphoma (NHL) (CAYA NHL) at the New York Sheraton Hotel and Towers in NYC, NY. The first two symposia were held at the same venue in NYC in 2003 and 2006 and the most recent in Frankfurt, Germany in 2009. Mitchell S. Cairo, MD and Alfred Reiter, MD have been the Chair and Co-Chair of all four of these international symposia on CAYA NHL. NHL in children and adolescents is an orphan (rare) disease accounting for only approximately 750-800 cases per year in the U.S. However, despite a dramatic improvement in the overall survival (OS) in CAYA with NHL over the past 30 yrs, there has been limited resources applied to increasing our understanding of the epidemiology, basic biology, development of novel translational and targeted therapies and long term effects of this orphan disease and almost negligible educational conference support. Adult NHL, a still rare but more common disease (55,000/yr/U.S.), with only a minimal increase in survival rates compared to CAYA NHL during the same 30 yr period, has in the past received substantially more NIH and biopharmaceutical educational conference support. Despite the improvement in 5yr OS in CAYA NHL, there are still a number of unanswered questions which require future critical investigations that would be facilitated in part following a multidisciplinary and multinational symposia on this subject matter The primary objectives of the proposed conference (Brief): 1) to present advances in the biology and treatment of CAYA with BL, DLBCL, LBL and ALCL; 2) to highlight new advances in diagnosis and treatment of rare histological subtypes including PTCL, T/NK NHL, and follicular NHL in CAYA patients; 3) to identify the genomics, proteomics and immunophenotypic features of CAYA NHL; 4) to characterize the biology and treatment and facilitate collaboration between pediatric and medical oncologists in the care of AYA with NHL; 5) to discuss new, novel and targeted therapeutic strategies in CAYA with NHL; 6) to develop humoral, cellular and stem cell therapy approaches in CAYA with NHL; Secondary objectives: 1) to promote the education, success and leadership of young investigators and investigators in training who perform research in CAYA with NHL; 2) to enhance international communication and collaboration with investigators taking care of CAYA with NHL; and 3) to provide educational opportunities for investigators working in less resourced socioeconomic environments that are involved in the care or research of CAYA with NHL. The results of the Fourth International Symposium will most likely increase our understanding of the basic, translational and clinical state of the scienc research in this rare disease and provide an opportunity and platform to engage young and senior multidisciplinary and multinational investigators to develop international collaborative research and develop less toxic and more molecular and immune targeted based research for future generations of patients with CAYA NHL. PUBLIC HEALTH RELEVANCE: This international symposium on childhood, adolescent and young adult non-Hodgkin lymphoma will be attended by multidisciplinary and multinational investigators. The educational program will facilitate new knowledge in this field, facilitate international collaborative research, enhance the maturation of young investigators in this specialty and bridge the clinical and scientific gap between pediatric and medical oncologists treating adolescents and young adults (AYA) with non-Hodgkin lymphoma.