COBRE: U OF KANSAS MEDICAL CTR: CENTER JOINT PROJECTS

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 我们召开了多次会议，以决定我们可能发展成计划项目的主题。 由于代谢综合征是一个主要的公共卫生问题，NASH（非酒精性脂肪性肝炎）是这种综合征的一个组成部分，我们决定检查可能导致这种现象的因素。 因此，我们设计了四个实验来研究小鼠的昼夜节律、各种遗传背景（品系）、各种饮食和年龄（老年）。 我们收集了其中三个实验的组织。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. We had a number of meetings to decide topics that we might develop into program projects. Because the metabolic syndrome is a major public health problem, and NASH (non-alcoholic steahepatitis) is a component of this syndrome, we decided to examine factors that might contribute to this phenomenon. Therefore, we have designed four experiments to investigate the circadian rhythm, various genetic backgrounds (strains), various diets, and ages (old) of mice. We have collected the tissues of three of these experiments.