Histology

描述：组织学核心的总体目标是提供组织病理学服务，以便病理生理学研究将得到定量形态数据的支持。组织学核心为组织学和细胞学分析提供专业知识和最先进的技术服务，所获得的数据以视觉和/或定量的形式呈现。组织学核心是上一个周期中细胞、组织和成像核心的延续。Core为肺细胞和组织提供了可靠的成像，并将在修订后的应用中继续提供这项基本服务。很容易看到细胞和细胞成分[例如，中性粒细胞、T细胞和巨噬细胞(及其颗粒)、胶原、弹性蛋白、毛细血管内皮细胞和周细胞以及基底膜]。核心还与组织病理学的新发展保持同步，并帮助参与的教员将适当的技术应用于他们的 研究项目。最后，核心帮助项目负责人准备用于出版和演示的图像。 需要强调的是，这一核心的服务远远超出了仅仅生产组织切片的范围。该中心提供有关组织学和细胞学制剂的知识、专业知识和解释。它帮助研究人员评估和设计使用这些技术的实验。 它还培训研究人员、博士后研究员、研究生和技术人员有关动物尸检、组织固定、组织病理学、免疫组织化学、原位杂交和图像分析的知识。作为新发现，核心工作人员还可以在组织病理学和形态测量技术的开发方面提供帮助 使它们成为必要的。

Description: The overall objective of the Histology Core is to provide histopathology services, so that pathophysiological invesfigafions will be backed by quantitative morphological data The Core provides expertise and state-of-the-art technical services for histologic and cytologic analyses, and the data obtained are presented in a visual and/or quantitative format. The Histology Core is a continuation ofthe Celt,Tissue, and Imaging Core in the previous cycle. The Core has provided reliable imaging of lung cells and tissues, and will continue to provide this essential service in the revised application. Cells and cell components can be easily visualized [e.g.,neutrophils, T cells, and macrophages (and their granules), collagen, elastin, capillary endothelial cells and pericytes, and basement membranes]. The Core also keeps abreast of new developments in histopathology and helps participating faculty apply the appropriate techniques to their research projects. Finally, the Core helps the project leaders prepare images for publication and presentation. It is important to emphasize that this Core's services extend far beyond those of just producing tissue sections. The Core provides knowledge, expertise and interpretation ofthe histological and cytological preparations produced. It helps the investigators evaluate and design experiments that use these techniques. It also trains investigators, postdoctoral fellows, graduate students and technicians in animal necropsy, Tissue fixafion, histopathology, immunohistochemistry, in situ hybridizafion, and image analysis. The Core staff can also provide assistance in the development of histopathologic and morphometric techniques as new findings make them necessary.