Administrative Core

RMRCE的战略计划是基于该计划过去的成功和那些已经成为真正的和在许多方面独特的RMRCE优势的活动。其中包括：1）在未充分研究的病原体，特别是伯克霍尔德氏菌和柯克斯氏菌方面建立国内和国际公认的专业知识和研究能力; 2）在整个地区利用新的BSL 3能力，包括落基山地区生物遏制实验室; 3）仅研究毒性选择剂而不是模式生物; 4）开发治疗和疫苗的广泛平台技术;这包括最初由科罗拉多州立大学开发的阳离子脂质DMA复合物（CLDC）， 和病毒研究项目; 5）高度综合的研究项目;和6）区域范围的RMRCE领导机构。这些都是RMRCE将利用的优势和机会 在接下来的五年里。此外，该战略计划考虑到了国家影响和发展研究所授权的、需要在农村监测、评价和教育框架下进行结构调整和重新确定重点的农村监测和教育活动。根据项目优势，制定了总体RMRCE结构（图1），以强调 针对特定主题领域的强大而灵活的研究计划 重要的是在生物防御和新兴传染病的整体国家努力 疾病研究，并得到科学核心的支持， 研究和促进产品开发。这种结构和战略 该计划也与该计划先前提出的目标保持一致。的细节 RMRCE和各个组件的操作在 行动计划（第A-2.4节）以及实现这一目标的优势和机会 组织结构详见A-2.1和A-2.2节。专题 在RMRCE战略计划的基础上讨论的领域在A节- 2.3.

The strategic plan for the RMRCE is based on the program's past successes and those activities that have emerged as true and in many ways unique RMRCE strengths. These include: 1) establishment of nationally and internationally recognized expertise and research capabilities in understudied pathogens, especially Burkholderia and Coxiella; 2) utilization of new BSL3 capabilities across the region, including the Rocky Mountain Regional Biocontainment Laboratory, 3) studies of only virulent Select Agents instead of model organisms; 4) development of broad-platform technologies for therapeutics and vaccines; this includes cationic lipid DMA complex (CLDC) originally developed at Colorado State University which will be used by bacterial and viral research projects alike; 5) highly integrated research projects; and 6) institution of region wide RMRCE leadership. These are the strengths and opportunities that the RMRCE will build on for the next 5 years. Additionally, the strategic plan takes into account NIAID mandated RCE activities that are in need of restructuring and refocusing under the RMRCE. Based on programmatic strengths the overall RMRCE structure (Figure 1) was developed to emphasize a robust and flexible research program that is directed at specific thematic areas important to the overall national effort in biodefense and emerging infectious diseases research, and that is supported by scientific cores designed to enhance research and facilitate product development. This structure and strategic plan also are aligned with the previously stated goals of this program. The details of the operation of the RMRCE and the individual components are described in the Action Plan (Section A-2.4) and the strengths and opportunities enabling this organizational structure are detailed in Sections A-2.1 and A-2.2. The thematic areas that from the basis of the RMRCE strategic plan are discussed in section A- 2.3.