Development Research Program

匹兹堡大学头颈部癌症发展研究计划将继续进行，以确定和促进头颈部癌症研究的创新试点项目。该计划的具体目标是：1）为有前途的头颈癌新研究的初步调查提供种子资金机会; 2）在头颈癌孢子高度优先的领域促进基础，临床和转化头颈癌研究; 3）促进试点项目发展成为头颈癌SPORE的完整项目状态，或与其他资助机构的独立研究者发起的提案竞争;以及4）增加头颈部癌症孢子活动的可见度，并增加该机构的临床医生和研究人员的参与。我们在这次更新申请中对发展研究计划的设计与第一次资助期间使用的过程相似，这被证明是成功的。Dr. William L.作者声明：M. Gollin和Jonas T.约翰逊，具有持续的管理经验， 发展计划，将继续为转化研究提供领导。发展研究计划将利用机构基于网络的资源和印刷公告，通知匹兹堡大学和卡内基梅隆大学的研究界提供研究资金，以支持头颈癌的试点项目。为了响应鼓励机构间合作的新SPORE指南，我们还将向费城的姐妹癌症中心提供该计划，这些癌症中心是美国宾夕法尼亚州癌症控制联盟（PAC-3）倡议的一部分。一个常设的发展研究计划委员会，以及来自UPCI、UPMC、头颈癌SPORE外部咨询委员会或其他头颈癌SPORE的具有特定专业知识的特设评审员，将对征集的项目提案进行严格和一致的同行评审。拟议的发展研究计划预算将包括通过本提案从NCI获得的每年10万美元的资金，以及从耳鼻喉科（通过匹兹堡眼耳基金会）和UPCI获得的每年10万美元的配套资金。每年将征求和审查建议书，最有价值的建议书将获得每年30，000至50，000美元的赠款，为期1至2年。发展研究计划的这些活动将继续刺激创新研究，以满足头颈癌孢子的转化目标：减少头颈癌的发病率，发病率和死亡率。

The Developmental Research Program of the University of Pittsburgh Head and Neck Cancer SPORE will continue to be carried out for the purpose of identifying and facilitating innovative new pilot projects in head and neck cancer research. The specific goals of this Program are: 1) to provide seed funding opportunities for initial investigation of promising novel research in head and neck cancer; 2) to stimulate basic, clinical, and translational head and neck cancer research in areas of high priority to the Head and Neck Cancer SPORE; 3) to facilitate development of pilot projects into full project status in the Head and Neck Cancer SPORE or to be competitive for independent Investigator-initiated proposals to other funding agencies; and 4) to increase the visibility of Head and Neck Cancer SPORE activities and increase participation among the institution's clinicians and researchers. Our design for the Developmental Research Program in this renewal application is similar to the process used during the first grant period, which proved successful. Drs. William L. Bigbee, Susanne M. Gollin and Jonas T. Johnson, with ongoing experience in administering this Developmental Program, will continue to provide leadership for translational research. The Developmental Research Program will utilize institutional web-based resources and printed announcements to notify the research community at the University of Pittsburgh and Carnegie Mellon University of the availability of research funds to support pilot projects in head and neck cancer. In response to the new SPORE guidelines encouraging inter-institutional collaboration, we will also make the program available to our sister Cancer Centers in Philadelphia, who are part of the stateside Pennsylvania Cancer Control Consortium (PAC-3) initiative. A standing Developmental Research Program Committee, together with ad hoc reviewers with specific expertise as needed drawn from the UPCI, UPMC, the Head and Neck Cancer SPORE External Advisory Board, or other Head and Neck SPOREs will provide rigorous and consistent peer review of the solicited project proposals. The proposed Developmental Research Program budget will include $100,000 per year in funds form the NCI through this proposal, together with an additional $100,000 per year in matching funds from the Department of Otolaryngology (through the Eye and Ear Foundation of Pittsburgh) and the UPCI. Proposals will be solicited and reviewed on an annual basis and grants of $30,000-$50,000 per year for 1-2 years will be awarded to the most meritorious proposals. These activities of the Developmental Research Program will continue to stimulate innovative research toward meeting the translational goals of the Head and Neck Cancer SPORE: reduction in the incidence, morbidity, and mortality from head and neck cancer.