PHYSIOLOGY CORE

生理学核心是YCCMD的核心组成部分，对中心的成功至关重要。这个 CORE由托马斯·卡彭特博士执导，由三个亚基组成。其中第一个， 组织学和组织形态计量学亚组准备不脱钙组织切片并进行特化 骨染色和组织形态计量学分析。骨的第二亚单位--生化标志物 营业部提供骨钙素、骨特异性碱性磷酸酶、酒石酸抗性酸的检测 磷酸酶、血清、P1NP和I型胶原C-端肽(CTX)作为骨吸收标志物。 第三个子单元，骨密度测量和成像提供pQCT，并与Dr.合作，目前 建立以最近收购的Sanco 35 UCT为特色的微型计算机断层扫描(UCT)设施 扫描仪。这些亚单位作为独立但相互关联的组成部分协同工作，以 提供一种全面的方法来分析各种动物模型。 生理学核心一直是该领域新手和初级研究人员的切入点，并已 极大地提高了整个医学院和更大范围内中心成员的生产力 大学研究社区。核心利用包括来自内务部的研究人员 医学，骨科和康复，儿科，外科，妇产科，遗传学，细胞 生物学、免疫生物学、生物学、比较医学和血液学。我们的培训努力已经取得了 更广阔的地理范围。 这一总体结构运作良好，我们将在下一年保持所述的组织形式 资金周期。随着服务需求的增加和营运开支的不断增加，我们 不得不应对某些财政挑战。我们的成本回收计划使我们能够在 九年收支平衡。此外，凭借高效的管理，我们保持了足够的 适度的收费结构，以限制差饷的增加，从而将对初级和首次的影响降至最低 调查人员。

The Physiology Core is a central component of the YCCMD and critical to the success of the Center. The Core is directed by Dr. Thomas Carpenter, and is comprised of three subunits. The first of these, the Histology and Histomorphometry subunit prepares undecalcified tissue sections and performs specialized staining of bone and histomorphpmetric analyses. The second subunit, Biochemical Markers of Bone Turnover offers assays for osteocalcin, bone specific alkaline phosphatase, tartrate resistant acid phosphatase, serum, P1NP, and the C-telopeptide of type 1 collagen (CTX) as a bone resorption marker. The third subunit, Bone Densitometry and Imaging offers pQCT and, in collaboration with Dr. is currently establishing a micro-computed tomographic (uCT) facility featuring a recently acquired Scanco 35 uCT scanner. These subunits, functioning as separate but interrelated components, work synergistically to provide a comprehensive approach to analyzing a wide range of animal models. The Physiology Core has been a focal point of entry for new and junior investigators in the field, and has greatly enhanced the productivity of Center members throughout the Medical School and in the larger University research community. Core utilization has included researchers from the Departments of Internal Medicine, Orthopaedics and Rehabilitation, Pediatrics, Surgery, Obstetrics and Gynecology, Genetics, Cell Biology, Immunobiology, Biology, Comparative Medicine, and Hematology. Our training efforts have had an even broader geographic reach. This overall structure has worked well and we will maintain the described organizational format for the next funding cycle. With increased demands for services and the invariable increase in operating expenses, we have had to meet certain fiscal challenges. Our cost recovery program has allowed us to operate with a balanced budget for 9 years. Moreover, with efficient management we have maintained a sufficiently modest fee structure as to limit rate increases, thereby minimizing the impact on junior and first time investigators.