Integrative tools for protozoan parasite research

描述(由申请人提供)：我们建议研究数据表示和集成工具，以促进对原生动物寄生虫基因组生物学的理解。这些工具中的许多也将对其他病原体有用，其中一些将用于提供到宿主的链接。在这项提案中，我们在顶端复合体和功能基因组数据库的先前成就的基础上，解决了可以通过数据整合和增强的数据处理来解决的关键问题。为了使病原体基因组数据库、算法和工具的数据集成成为可能，我们将在开放生物医学本体(OBO)Foundry的背景下开发必要的语义(本体)。我们还将进一步开发WebProtigi，以促进本体的协作构建和本体的集成。利用这些语义，我们将开发新的工具，通过构建Web服务和Galaxy开源平台，在不专门开发软件的情况下实现大规模数据分析，从而促进对原生动物和与宿主(人类、老鼠和其他脊椎动物)的联系的研究。 公共卫生相关性：原生动物寄生虫，如那些引起疟疾和弓形虫病的寄生虫，仍然是全球健康的主要威胁，也是一个重大的生物防御问题。目前的治疗方法是有限的，有时还会受到获得性耐药性的影响。解决方案将来自对正在进行的研究的整合和挖掘。拟议的研究将提供新的框架和工具，以促进基因组规模数据集的数据集成和计算挖掘。

DESCRIPTION (provided by applicant): We propose research on data-representation and integration tools to advance understanding of protozoan parasite genome biology. Many of these tools will also be useful for other pathogens and some will be useful for providing links to the host. In this proposal, we build on previous accomplishments with apicomplexan and functional genomic databases to attack critical problems that can be addressed through data integration and enhanced data processing. In order to make data integration possible for pathogen genome databases, algorithms and tools, we will develop the necessary semantics (ontologies) in the context of the Open Biomedical Ontologies (OBO) Foundry. We will also further develop WebProtigi to facilitate collaborative ontology building and integration of ontologies. Taking advantage of these semantics, we will develop new tools to facilitate research on protozoan and links to hosts (human, mouse and other vertebrates), by building upon Web services and the Galaxy open source platform to enable large-scale data analysis without dedicated software development. PUBLIC HEALTH RELEVANCE: Protozoan parasites such as those that cause malaria and toxoplasmosis remain major threats to global health, and a significant biodefense concern. Current treatments are limited and sometimes compromised by acquired resistance. Solutions will come from the integration and mining of ongoing research. The proposed research will provide new frameworks and tools to facilitate data integration and computational mining of genomic-scale datasets.