Methamphetamine Abuse Research Center

俄勒冈州是少数几个招募没有较大可卡因滥用史的甲基苯丙胺(MA)滥用者进行临床研究的州之一。此次更新的甲基苯丙胺滥用研究中心(MARC)将在分子、遗传、神经化学、解剖学、行为和临床水平上表征MA的影响，以确定MA滥用者康复的风险和障碍。集成的临床前和临床研究部分使用一些常见的方法，解决与MA相关的神经适应、神经回路和神经免疫效应的主题。这一更新继续进行双向翻译研究，在这种研究中，人类和动物的结果相互告知。该中心的行政核心1监督预算问题，并促进MARC调查人员之间的互动，生物统计和遗传学核心2提供统计和遗传分析服务。动物核心3号为MARC研究人员提供遗传动物模型和一些行为测试服务。教育核心4协调医学博士和博士博士研究生和博士后研究员的研究培训，并将MARC研究人员的临床和临床前信息传播到受MA滥用影响的其他中心和更多农村地区。翻译服务核心5招募和鉴定受试者，并对饮用人类和MA的选定小鼠品系样本进行相同的生化分析。试点项目核心6支持在滥用MA的研究方面发展多个新方向。科学部分7将图像分析结果与人类和动物受试者的冲动决策联系起来。科学组成部分8研究了免疫功能在人类认知反应中的作用，并在小鼠身上测试了一种新的免疫疗法，科学组成部分9使用MA饮用选定的小鼠品系来检查免疫功能在MA自我管理风险中的作用，以及这种风险如何与MA对免疫功能的影响相互作用。数据和样本是跨组件共享和比较的。因此，MARC使用综合的、创新的、多学科的和翻译的方法来解决临床相关的主题。

Oregon is one of a few states where methamphetamine (MA) abusers without a greater history of cocaine abuse are recruited for clinical research. This renewal of the Methamphetamine Abuse Research Center (MARC) will characterize effects of MA at molecular, genetic, neurochemical, anatomical, behavioral, and clinical levels, to identify risks and obstacles to recovery in MA abusers. Integrated preclinical and clinical research components use some common methodologies and address MA-related themes of neuroadaptation, neurocircuitry, and neuroimmune effects. This renewal continues to pursue bidirectional translational research in which human and animal results inform one another. The Center's Administrative Core 1 supervises budgetary issues and facilitates interactions among MARC investigators, and the Biostatistics and Genetics Core 2 provides statistical and genetic analysis services. The Animal Core 3 provides genetic animal models and some behavioral testing services to MARC investigators. The Education Core 4 coordinates the research training of M.D. and Ph.D. pre- and post-doctoral fellows, and disseminates clinical and preclinical information from MARC investigators to other Centers and more rural areas that are impacted by MA abuse. The Translational Service Core 5 recruits and characterizes subjects and conducts identical biochemical assays on human and MA drinking selected mouse line samples. The Pilot Projects Core 6 supports the development of multiple new directions in research on MA abuse. Scientific Component 7 associates image analysis results with impulsive decision making in human and animal subjects. Scientific Component 8 examines the role of immune function in human cognitive response and tests a novel immunotherapy in mice, and Scientific Component 9 uses MA drinking selected mouse lines to examine the role of immune function in the risk for MA self-administration and how this risk interacts with MA effects on immune function. Data and samples are shared and compared across components. Thus, the MARC addresses clinically relevant themes using integrated, innovative, multidisciplinary, and translational approaches.