Understanding Motor Behavior After Stroke

描述（由申请人提供）：中风后运动功能的恢复通常不理想。因此，我们需要阐明当我们学习新的运动行为时，中风患者的大脑是如何工作的。为此，我们建议将运动学习分解为多个部分，并测试大脑刺激如何影响这些部分。我们的研究结果将告知我们如何计划和提供运动训练练习，以康复中风患者。重要的是，这里学到的策略可能适用于其他神经系统患者群体。 公共卫生相关性：中风后运动功能的恢复通常不理想。出于这个原因，许多调查一直在解决如何提高体育训练的效果，这是公认的改善恢复的主要干预措施之一。其中一个有前途的新干预措施是应用非侵入性脑刺激。为了更好地理解大脑刺激的潜力，我们需要阐明当我们学习新的运动行为时大脑是如何工作的，以及这种干预如何与大脑相互作用。在这项提案中，我们计划研究中风患者如何学习新的运动行为。为此，我们建议将运动学习分解为多个部分，并测试大脑刺激如何影响这些部分。我们的研究结果将告知我们如何计划和提供运动训练练习，以康复中风患者。重要的是，这里学到的策略可能适用于其他神经系统患者群体。

DESCRIPTION (provided by applicant): Recovery of motor function following stroke is usually suboptimal. Thus, we need to elucidate how the brain of patients with stroke works when we learn new motor behaviors. To this end, we propose to decompose motor learning into multiple components and test how brain stimulation affects each of these parts. The findings of our study will inform how we plan and deliver motor training exercises to rehabilitate patients with stroke. Importantly, the strategies learned here would likely be applicable to other neurological patient populations. PUBLIC HEALTH RELEVANCE: Recovery of motor function following stroke is usually suboptimal. For this reason many investigations have been addressing how to enhance the effects of physical training, one of the main recognized interventions to improve recovery. One of the promising new interventions is the application of non-invasive brain stimulation. To better understand the potential of brain stimulation, we need to elucidate how the brain works when we learn new motor behaviors and how this intervention interacts with the brain. In this proposal, we plan to investigate how patients with stroke learn new motor behaviors. To this end, we propose to decompose motor learning into multiple components and test how brain stimulation affects each of these parts. The findings of our study will inform how we plan and deliver motor training exercises to rehabilitate patients with stroke. Importantly, the strategies learned here would likely be applicable to other neurological patient populations.