Enabling Technologies to Macromolecular Crystallization

结构生物学，研究生物学上重要分子的形状，是一门基础科学， 对生命的理解;它主要是单晶衍射研究的结果。项目“使 高分子结晶技术”是对高通量研究实验室工作的扩展 （HTSlab），位于纽约州布法罗的Hauptman-Woodward研究所的大分子结晶设施。的 HTSlab专注于开发高通量方法来生长大分子晶体 适用于衍射研究;这种晶体的形成是衍射科学中的一个重要瓶颈。 结构生物学我们将继续与普通生物学、结构生物学和结构生物学合作， 基因组学小组进行结晶试验，并使这些试验的分析多达1000 大分子每年。我们将在三个方面开展工作：提供结晶专业知识， 为三个生物社区的成员提供服务;结晶的开发和测试 高通量环境中的方法和材料;以及信息学服务和 结晶结果分析工具。我们希望与PSI社区密切合作， 指导其进一步努力对复杂系统的生物学更深入的理解。

Structural biology, the study of the shapes of biologically important molecules, is a foundational science in the understanding of life; it is principally the result of single crystal diffraction studies. The project "Enabling Technologies for Macromolecular Crystallization" expands upon the work of the High Throughput Search Lab (HTSlab), a macromolecular crystallization facility at the Hauptman-Woodward Institute in Buffalo, NY. The HTSlab specializes in the development of high throughput methods to grow crystals of macromolecules suitable for diffraction studies; the formation of such crystals is a significant bottleneck in the science of structural biology. We will continue to partner with general biology, structural biology and structural genomics groups to undertake crystallization trials and enable analysis of these trials on as many as 1000 macromolecules each year. We will work in three areas: the provision of crystallization expertise and services for members of the three biology communities; the development and testing of crystallization methods and materials in a high throughput environment; and the integration of informatics services and tools for the analysis of crystallization results. We expect to work closely with the PSI community as it directs its further efforts toward a deeper understanding of the biology of complex systems.