The Biology and Chemistry of Traditionally Used Anti-Diabetic Botanical Drugs

描述（由申请人提供）：2型糖尿病是世界上一个毁灭性的健康问题，特别是在美国。胰岛素模拟剂（IMA）和胰岛素增敏剂（ISA）是用于对抗这种疾病的两种类型的抗糖尿病药物，它们是开发新治疗方法的活跃研究领域。本项目旨在从山茱萸和泽泻中分离和鉴定新的IMA和/或ISA，这两种植物用于治疗糖尿病的传统中药。通过一系列跟踪原代和培养脂肪细胞中毒性和胰岛素依赖性葡萄糖摄取的体外生物测定，将分离和鉴定活性组分。这项研究的结果将有助于 作为含有这些植物的抗糖尿病配方标准化的基线数据，并为抗糖尿病药物的药物开发提供先导化合物。 公共卫生相关性：该项目旨在从传统中药中使用的两种植物中分离抗糖尿病化合物。这项拟议的工作与公共卫生有关，因为2型糖尿病是美国第七大死亡原因，所有迹象表明，如果不开发新的更好的药物，这一数字将不会改善。植物，特别是那些有治疗糖尿病历史的植物，是发现先导化合物的极好来源，这些化合物可能被开发成新一代药物。此外，用于治疗糖尿病的草药制剂的活性成分的标准化预计将导致安全有效的治疗选择。

DESCRIPTION (provided by applicant): Type 2 diabetes is a devastating health problem of the world, especially in the United States. Insulin mimetic agents (IMAs) and insulin sensitizing agents (ISAs) are two types of anti-diabetic agents being used to combat this disease, and they are active areas of research for developing new treatments. This project seeks to isolate and identify novel IMAs and/or ISAs from Cornus officinalis and Alisma orientale, two plant species used in traditional Chinese medicine for the treatment of diabetes. Through a series of in vitro bioassays tracking toxicity and insulin dependent glucose uptake in primary and cultured adipocytes, active components will be isolated and identified. The results of this study will serve as baseline data for the standardization of anti-diabetic formulas containing these plants, and provide lead compounds for the pharmaceutical development of anti-diabetic drugs. PUBLIC HEALTH RELEVANCE: This project seeks to isolate anti-diabetic compounds from two plant species used in traditional Chinese medicine. The proposed work is relevant to public health because Type-2-diabetes is the seventh leading cause of death in the United States, and all indications suggest that this number will not improve without the development of new and better drugs. Plants, especially those with a history of use to treat diabetes, are an excellent source for the discovery of lead compounds, which may be developed into a new generation of pharmaceuticals. Furthermore, the standardization by active ingredients of herbal preparations in use to treat diabetes is expected to lead to safe and effective treatment options.