Development Research Program

匹兹堡大学头颈部癌症孢子开发研究计划将继续实施，以确定和促进头颈部癌症研究的创新试点项目。这一计划的具体目标是：1)为头颈部癌症有前景的新研究的初步研究提供种子资金机会；2)在头颈部癌症孢子的高度优先领域刺激头颈癌的基础、临床和转化性研究；3)促进头颈部癌症孢子的试点项目发展成为全面项目，或在向其他资助机构提出的独立研究人员发起的提案中具有竞争力；以及4)提高头颈部癌症孢子活动的知名度，并增加机构临床医生和研究人员的参与。我们在这次续签申请中为发展研究计划设计的程序类似于第一次拨款期间使用的程序，事实证明是成功的。威廉·L·比格比博士、苏珊·M·戈林博士和乔纳斯·T·约翰逊博士，具有持续的管理经验 发展计划，将继续为翻译研究提供领导。发展研究计划将利用机构基于网络的资源和印刷公告，通知匹兹堡大学和卡内基梅隆大学的研究社区有可用的研究资金来支持头颈部癌症的试点项目。作为对鼓励机构间合作的新孢子指南的回应，我们还将向我们在费城的姊妹癌症中心提供该计划，他们是美国宾夕法尼亚州癌症控制联盟(PAC-3)倡议的一部分。一个常设的发展研究计划委员会，以及来自UPCI、UPMC、头颈部癌症孢子外部咨询委员会或其他头颈部孢子的具有特定专业知识的特别评审员，将对征求的项目提案进行严格和一致的同行评审。拟议的发展研究计划预算将包括NCI通过这项提案每年提供的10万美元资金，以及耳鼻喉科(通过匹兹堡眼耳基金会)和UPCI每年额外提供的10万美元配套资金。提案将每年征求和审查，最有价值的提案将在1-2年内每年获得30,000-50,000美元的赠款。发展研究计划的这些活动将继续促进创新研究，以实现头颈部癌症孢子的翻译目标：降低头颈部癌症的发病率、发病率和死亡率。

The Developmental Research Program of the University of Pittsburgh Head and Neck Cancer SPORE will continue to be carried out for the purpose of identifying and facilitating innovative new pilot projects in head and neck cancer research. The specific goals of this Program are: 1) to provide seed funding opportunities for initial investigation of promising novel research in head and neck cancer; 2) to stimulate basic, clinical, and translational head and neck cancer research in areas of high priority to the Head and Neck Cancer SPORE; 3) to facilitate development of pilot projects into full project status in the Head and Neck Cancer SPORE or to be competitive for independent Investigator-initiated proposals to other funding agencies; and 4) to increase the visibility of Head and Neck Cancer SPORE activities and increase participation among the institution's clinicians and researchers. Our design for the Developmental Research Program in this renewal application is similar to the process used during the first grant period, which proved successful. Drs. William L. Bigbee, Susanne M. Gollin and Jonas T. Johnson, with ongoing experience in administering this Developmental Program, will continue to provide leadership for translational research. The Developmental Research Program will utilize institutional web-based resources and printed announcements to notify the research community at the University of Pittsburgh and Carnegie Mellon University of the availability of research funds to support pilot projects in head and neck cancer. In response to the new SPORE guidelines encouraging inter-institutional collaboration, we will also make the program available to our sister Cancer Centers in Philadelphia, who are part of the stateside Pennsylvania Cancer Control Consortium (PAC-3) initiative. A standing Developmental Research Program Committee, together with ad hoc reviewers with specific expertise as needed drawn from the UPCI, UPMC, the Head and Neck Cancer SPORE External Advisory Board, or other Head and Neck SPOREs will provide rigorous and consistent peer review of the solicited project proposals. The proposed Developmental Research Program budget will include $100,000 per year in funds form the NCI through this proposal, together with an additional $100,000 per year in matching funds from the Department of Otolaryngology (through the Eye and Ear Foundation of Pittsburgh) and the UPCI. Proposals will be solicited and reviewed on an annual basis and grants of $30,000-$50,000 per year for 1-2 years will be awarded to the most meritorious proposals. These activities of the Developmental Research Program will continue to stimulate innovative research toward meeting the translational goals of the Head and Neck Cancer SPORE: reduction in the incidence, morbidity, and mortality from head and neck cancer.