Mouse Transplantation

小鼠移植(核心成分B) 这一核心旨在为几种品系的小鼠提供集中的、专门的动物护理，包括 NOD/SCID及其变异体以及绿色荧光蛋白和Flt3转基因基因的选育。免疫缺陷和免疫缺陷的选育 转基因小鼠是必要的，因为这些品系中的许多在商业上也没有 我们的学习所需的数量，或者根本不需要。大量需要移植和监测的小鼠 嫁接是核心的另一个主要功能。我们相信，集中提供专业知识 这些服务无论在科学上还是在财务上都是有效的。 相关性 组织特异性干细胞和癌症干细胞的鉴定是该计划项目的主要目标。这个 CORE将提供资源，帮助鉴定这些稀有细胞类型，并建立这些细胞的生物学 着眼于使用获得的生物信息来治疗癌症和损伤。

Mouse Transplantation (Core Component B) This core is designed to provide centralized, specialized animal care for several strains of mice to include breeding of Nod/Scid and variants as well as EGFP and Flt3 transgenics. Breeding of immuno-deficient and transgenic mice are necessary because many of these strains are not commercially available either in quantities needed for our studies or not at all. The large number of mice to be transplanted and monitored for engraftment represents the other major function of the core. We believe providing the expertise centrally for these services is efficient both scientifically and financially. Relevance The identification of tissue specific and cancer stem cells are the primary goals of this program project. The core will provide a resource to help identify these rare cell types and establish the biology of these cells with an eye toward using the biological information gained toward treating cancer and injury.