TAS::75 0893::TAS RAPID QUANTITATIVE POINT OF CARE TEST FOR NICOTINE METABOLITE

最近的临床研究证实，这一比率表明了代谢尼古丁的CYP2A6酶的活性。尼古丁被代谢到COT，然后再代谢到3HC。这种酶活性高的人清除尼古丁的速度更快，因此需要更多的尼古丁来维持成瘾。到目前为止，3HC/COT的比率只能通过专门的测量技术来确定，如液相色谱/质谱仪。虽然准确，但这些测试费用昂贵，需要2-5天才能得出结果。 吸烟是癌症相关死亡的主要原因，也是美国每年近40万人死亡的原因；尼古丁代谢物的POCT有助于提高戒烟率，并直接有助于降低死亡率/医疗负担。

Recent clinical research has established that this ratio is indicative of the activity of the CYP2A6 enzyme that metabolises nicotine. Nicotine is metabolized to COT and then to 3HC. People with high activity of this enzyme, clear nicotine faster and hence need more nicotine to maintain the addiction. To-date the 3HC/COT ratio could only be determined by specialized measurement techniques such as Liquid-Chromatography/Mass Spectrometry. Although accurate, these tests are expensive and take 2-5 days to deliver results. Smoking is the leading cause of cancer related deaths, and is attributable cause for almost 400,000 deaths per year in the US> The POCT for nicotine metabolites can help in increasing smoking cessation rates and directly contribute to reduced mortality/healthcare burden.