Research Core

项目总结(见说明)： 前列腺癌是美国男性癌症死亡的第二大原因，仅次于皮肤癌。在非洲裔美国男性中，前列腺癌的发病率比高加索男性高65%，死亡率是白人男性的两倍多。非裔美国人发病率和死亡率存在种族差异的原因目前还不清楚，但可能涉及生物和环境因素。克拉克·亚特兰大大学癌症研究和治疗发展中心(CCRTD)正在继续建立一项全面的研究计划，以调查前列腺癌转化、血管生成和转移所涉及的细胞和遗传因素，以及这些因素在非裔美国人男性中的不同之处。这一更新应用中的三个研究项目将研究1)转化生长因子β信号在前列腺癌不同阶段中的作用，2)雄激素调节的免疫/炎症通路在前列腺癌中的影响，以及3)蜗牛转录因子在前列腺癌骨转移中的作用。所有研究人员都住在同一栋大楼里，可以进入最先进的研究核心实验室。这些核心在细胞生物学/成像、分子生物学、组织学、蛋白质组学、结构生物学和生物信息学、组织储存库和基因组学方面提供仪器和技术援助。这些设施由一名高级研究科学家和一名设施协调员管理。为个别项目产生的试剂、临床样本和材料将由研究核心处理，并由所有研究人员共享。个别研究人员的研究项目基于非常互动的方法，并为CCRTD的多名研究人员和其他几个机构的科学家之间的合作提供了机会。不同项目的项目主管和研究人员每周举行一次会议，监测和讨论个别项目的进展情况。该中心的科学计划由内部和外部咨询委员会监督，这些委员会有前列腺癌、生物学和化学领域的几名成员。

PROJECT SUMMARY (See instructions): Prostate cancer is the second leading of cancer deaths among american men after skin cancer. In African- American men, the incidence of prostate cancer is 65% higher and the mortality rate is more than double compared to Caucasian men. The reasons for this racial disparity in incidence and death rate in African Americans are poorly understood, but may involve both biological and environmental factors. The Center for Cancer Research and Therapeutic Development (CCRTD) at Clark Atlanta University is continuing to build a comprehensive research program to investigate the cellular and genetic factors involved in transformation, angiogenesis and metastasis of prostate cancer and how these factors may differ in African-American men. Three research projects in this renewal application will investigate 1) Role of TGFbeta signaling during different phases of prostate cancer, 2) Impact of androgen regulated immune/inflammatory pathways in prostate cancer, and 3) The role;of SNAIL transcription factor in prostate cancer bone metastasis. All investigators are housed in the same building and have access to state-of-the art research core laboratories. These cores provide instrumentation and technical assistance in cell biology/imaging, molecular biology, histology, proteomics, structural biology and bioinformatics, tissue repository and genomics. These facilities are managed by a Senior Research Scientist and a Facilities Coordinator. The reagents, clinical samples and materials generated for individual projects will be handled by the research core and will be shared by all investigators. The research projects from individual investigators are based on very interactive approaches and provide opportunities for collaborations among multiple investigators at CCRTD and scientists at several other institutions. The Pis of the different projects and the research staff meet once a week to monitor and discuss the progress of individual projects. The scientific program of the center is overseen by internal and external advisory committees with several members in the area of prostate cancer biology and chemistry.