AIDS INFRASTRUCTURE AND RESEARCH DEVELOPMENT

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 目标一扩大我们目前的研究团队，招募博士后候选人，并通过全面的发展计划提高他们的职业生涯 AIM 1.确定并招募三名合适的候选人。 AIM 2.在候选人和PI之间进行协商的情况下，根据研究小组的当前需求为每位候选人制定研究项目和计划。 目标二。建立必要的组织结构，以加强Nef发病机制小组（NPG）的研究和资助。 AIM 1.设立艾滋病毒/艾滋病发病机制咨询小组委员会。 AIM 2.为小组活动提供研究支持。 AIM 3.组织男男性接触者艾滋病毒研究的各个组成部分 AIM 4.加强我们目前的蛋白质组学和成像能力，以支持发病机制组的研究。 研究重点：了解HIV-1 Nef致病作用导致艾滋病的作用和机制。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Objective I. Extend our current research team recruiting postdoctoral candidates, and enhancing their careers through a comprehensive developmental program AIM 1. Identify and recruit three suitable candidates. AIM 2. Develop a research project and plan for each candidate from the current needs of the research group with consultation between the candidate and the PIs. Objective II. Establish the organizational structure necessary to enhance the research and the funding of the Nef Pathogenesis Group (NPG). AIM 1. Establish an HIV/AIDS Pathogenesis Advisory Subcommittee. AIM 2. Build research support for the group activities. AIM 3. Organize the various components of HIV research at MSM AIM 4. Enhance our current proteomics and imaging capability to support research of the Pathogenesis group. Research Focus: Understanding the Role Played by and Mechanisms Underlying HIV-1 Nef's Pathogenic Effects Leading to AIDS.