R&D-OTHER R & D-B RES

Agiltron提出开发高深度分辨率、高速度、高灵敏度的兔眼全前房体积光学相干显微成像技术，定量评估眼部刺激试验中初始损伤的深度和程度（001）。Jester博士率先开展的研究提供了强有力的证据，证明001是一种客观和通用的生物标志物，可以在比目前定义的人类终点早得多的时间点上确定各种化学品的毒性严重程度。Agiltron提出的4-0 （X， Y， Z, t）光学相干成像具有超高深度分辨率、大深度范围和广域覆盖等关键特性。此外，超高速可以有效去除活体动物的运动伪影。因此，成像技术提供了最合适的工具来准确评估初始损伤的深度、面积和体积以及恢复过程中的后期反应。特别是，将开发新的3D配准和分割技术，以便对同一组织附近（XYZ维度）但不同时间点（t维度）的刺激进展和伤口愈合进行点对点比较，以进行定量，客观和敏感的眼部安全性评估以及早期的人体终点。

Agiltron proposes to develop volumetric optical coherence microscopic imaging technology for the full anterior chamber of the rabbit eye with high depth resolution, high speed, and high sensitivity to quantitatively assess the depth and extent of initial injury (001) in ocular irritant test. Studies pioneered by Dr. Jester have provided strong evidence that 001 is an objective and universal biomarker to determine the severity of toxicity for various chemicals at time points much earlier than currently defined humane endpoints. The 4-0 (X, Y, Z, and t) optical coherence imaging proposed by Agiltron has the key properties in ultrahigh depth resolution, large depth range, and wide area coverage. In addition, the ultrahigh speed can effectively remove motion artifacts of living animals. Therefore the imaging technology provides the most appropriate tool to accurately evaluate the depth, area, and volume of the initial injury as well as the later responses in recovery. In particular, novel 3D registration and segmentation technology will be developed to enable the point-to-point comparison of the irritation progression and wound healing at the same tissue vicinity (XYZ dimensions) but different time points (t dimension) for quantitative, objective, and sensitive ocular safety assessments as well as the earlier human endpoints.