NONHUMAN PRIMATE STUDIES OF METHAMPHETAMINE/HEROIN ABUSE

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 药物滥用仍然是一种持续的流行病，逃避有效的治疗。多重依赖带来了进一步的挑战，因为需要治疗不同物质的不同心理和生理影响。这一提议有可能区分冰毒和海洛因滥用的个别影响的生物学基础，并揭示它们如何协同行动产生快球效应。了解速球奖赏的药理学将导致精确的大脑靶点，针对这些靶点，可以开发药物来抵消速球的奖赏效应，从而减少对速球依赖的流行。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Substance abuse continues to be a persistent epidemic that evades effective treatment. Multiple dependencies present a further challenge because of the need to treat different psychological and physiological effects of the different substances. This proposal has the potential to distinguish the biological basis of individual effects of METH and heroin abuse and reveal how they act in tandem to produce a speedball effect. Understanding the pharmacology of speedball reward will lead to the precise brain targets for which medications can be developed to counteract the rewarding effects of speedballs and consequently reduce the prevalence of speedball dependence.