REGULATORY MECHANISM OF HEPARIN/HEPARAN SULFATE ON VEGF SIGNALING

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 已知肝素和肝素样分子调节内皮细胞对血管内皮生长因子-A（VEGF-A）的反应。在这项合作中，我们一直在研究肝素/硫酸乙酰肝素的影响VEGF-A的生物活性的可能机制，使用硫酸乙酰肝素缺陷的小鼠内皮细胞系来源于硫酸乙酰肝素突变小鼠。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Heparin and heparin-like molecules are known to modulate the responses of endothelial cells to vascular endothelial growth factor-A (VEGF-A). In this collaboration, we have been investigating the likely mechanisms for heparin/heparan sulfate's influence on the biological activity of VEGF-A using heparan sulfate deficient mouse endothelial cell lines derived from heparan sulfate mutant mice.