REPRODUCIBILITY OF US, CT, MR PERFUSION IMAGING OF COLON CANCER XENOGRAFT MODEL

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 本研究的目的是比较使用微泡（SonoVue）、碘基造影剂（例如Isovue）和钆基造影剂在肿瘤模型（最可能是结肠癌异种移植物）中进行US、CT和MR灌注成像的重现性。 在对超声设备进行初步培训后，这将成为一个服务项目，由研究人员运行设备。体内显微镜中心的参与安排劳伦斯·赫德伦博士从皮埃蒙特研究中心（LSW 480结肠肿瘤）交付小鼠。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The aim of this study is to compare reproducibility of US, CT, and MR-perfusion imaging in a tumor model (most likely colon cancer xenograft) using Microbubbles (SonoVue), an iodine-based contrast agent (e.g. Isovue), and a gadolinium based contrast agent. After initial training on the ultrasound equipment, this will become a service project, with the investigators running the equipment. The participation of the Center for In Vivo Microscopy is arranging for delivery by Dr. Laurence Hedlund of the mice from Piedmont Research Center (LSW480 colon tumors)